Gene expression profiles being predictive for the response of tumors to pharmaceutically effective compounds

ABSTRACT

The present invention relates to a method for providing a gene expression profile being predictive for the specific response of an individual tumor to a pharmaceutically effective compound, the use thereof, a microarray wherein the nucleotide sequences attached to the substrate consist of nucleotide sequences corresponding to the predictive genes of said gene expression profile, and a diagnostic kit containing said microarray.

This application is a section 371 U.S. National phase application of international application no. PCT/EP2006/003421, filed Apr. 13, 2006, which claims the benefit of priority to EP application no. 05008088, filed Apr. 13, 2005 and U.S. Provisional application No. 60/670,863, filed Apr. 13, 2005.

The present invention relates to a method for providing a gene expression profile being predictive for the specific response of an individual tumor to a pharmaceutically effective compound, the use thereof, a microarray wherein the nucleotide sequences attached to the substrate consist of nucleotide sequences corresponding to the predictive genes of said gene expression profile, and a diagnostic kit containing said microarray.

Gene expression profiles reflect the relative expression level of transcription units by determining the amount of mRNA expressed. Changes in the expression levels of genes up- or down-regulated in cancerous cells can be determined when comparing the gene expression profile of highly and moderately responsive tumor tissue with the gene expression profile of resistant tumor tissue.

The so-called microarray analysis is a useful method for a highly efficient analysis of gene expression profiles. A microarray is an ordered array of genes immobilized on a planar substrate that allows the specific binding of labeled nucleic acids. Microarray technologies which can be used for analyzing gene expression profiles involve depositing nucleic acids on a solid platform in a set pattern, and hybridizing a solution of complementary nucleic acids to the nucleic acid targets. Microarray technology has been applied increasingly in this field due to its capability to illustrate the cancerous changes in the cellular behavior on a genomic level.

One of the main problems when identifying genes which predict the treatment-response of an individual tumor is the lack of a sufficient large number of different tumors being characterized for both their chemosensitivity and mRNA expression. Cell lines and cell line derived xenografts do not have enough predictive capabilities for a clinical use for evaluating genes in question. In investigating tumors only a few pharmaceutically effective compounds can be evaluated in a single tumor model and today most tumor types are treated with combination chemotherapy.

In the prior art methods for obtaining gene expression profiles of tumor material are established for one individual tumor type and are not transferable to other tumor types. Further, most of the methods known in the prior art use a two sided t-test to choose the genes differentially expressed in only two classification groups for the responsiveness of a tumor to the treatment with a pharmaceutically effective compound, i.e. sensitive and resistant. The main drawback of this method is the fact, that this procedure has a high risk of getting a large number of “false positive” genes which are differentially expressed in the different groups only by chance.

Thus, the technical problem underlying the present invention is to provide a new method for predicting the responsiveness of an individual tumor to a pharmaceutically effective compound.

The solution to the above technical problem is achieved by the embodiments characterized in the claims.

In particular, the present invention relates to a method for providing a gene expression profile being predictive for the specific response of an individual tumor to a pharmaceutically effective compound, comprising the steps of

-   -   (a) xenotransplanting human tumor material of at least five         different tumors into at least one suitable test animal,         preferably a nude mouse,     -   (b) determining the gene expression profiles of the resulting         tumor xenografts,     -   (c) treating said at least one test animal with a         pharmaceutically effective compound,     -   (d) evaluating the responsiveness of the tumor xenografts to the         pharmaceutically effective compound,     -   (e) identifying the gene expression profile of each of the         tested tumor xenografts, and     -   (f) determining the predictive genes in the gene expression         profiles by comparing the gene expression profiles of the         responsive tumors, the no-change tumors and the progressive         tumors.

According to the present invention, the human tumor material being xenotransplanted into at least one suitable test animal, preferably a nude mouse, can be any human tumor material, e.g. derived from bladder, breast, colon, CNS, head and neck, liver, gallbladder, lung (small cell and non small cell), kidney, ovarian, pancreas, pleura, prostate, stomach, testicle, and uterus tumors, sarcomas, melanomas, and lymphomas. In a preferred embodiment of the present invention tumor material derived from different tumor types is transplanted into at least one nude mouse in step (a) of the above method, so that the predictive genes determined in step (f) of the above method are found in gene expression profiles of different tumor types.

In a preferred embodiment of the present invention each different tumor is xenotransplanted into one suitable test animal. For example, human tumor material of at least 15, more preferably at least 30, most preferably from 30 to 50 different tumors are each xenotransplanted into a different test animal, thereby resulting in at least 15, more preferably at least 30, most preferably from 30 to 50 different xenotransplanted test animals, preferably nude mice.

In a preferred embodiment of the present invention the human tumor material being xenotransplanted into the at least one test animal is derived from the tumor types shown in Table 2.

The term “xenografts” as used herein means patient-derived human tumor xenografts which have never been transformed into a cell line and have always been passaged directly into and through test animals, preferably nude mice. They have proven to have a high capability of predicting chemosensitivity to anti-cancer agents regarding the clinical situation of patients. For this reason they are a preferred choice for acquiring chemosensitivity data and gene expression profiles for the corresponding tumor samples.

The term “gene expression profile” as used herein refers to the relative expression of a plurality of mRNA transcripts or post-transcriptional level including protein amounts and post-translational modifications. A gene expression profile of a human tumor xenograft or a human tumor tissue reflects the amount of each mRNA transcript and/or post-transcriptional level in the starting sample. In a preferred embodiment of the present invention the gene expression profiles of the tumor xenografts is obtained using e.g. microarray techniques, PCR, Northern-analysis, etc.

The evaluation of the responsiveness of the tumor xenografts to the pharmaceutically effective compound has been carried out by determining the T/C (therapy/control) values of each tumor. The T/C value of each tumor can be determined by comparing the size of a tumor treated with a pharmaceutically effective compound (therapy) with the size of the untreated tumor (control). After all measurements at various time points are carried out the minimal value representing the best compound effect is taken for evaluation. If for example a tumor treated with a pharmaceutically effective compound has 20% of the size of an untreated tumor then the respective T/C value of the tumor treated with a pharmaceutically effective compound is 20% which equals to a tumor growth inhibition property of said pharmaceutically effective compound of 80%.

In preferred embodiments of the present invention a tumor xenograft is considered to be responsive when its T/C (therapy/control) value is e.g. less than 25%, a tumor xenograft is considered to be no-change when its T/C value is e.g. 25% or more and e.g. 42% or less, and a tumor xenograft is considered to be progressive when its T/C (therapy/control) value is e.g. more than 42%. In contrast to the prior art the present invention uses three groups which is much closer to the clinical situation than only using two.

In order to determine the predictive genes at least two of the groups selected from the group consisting of responsive, no-change, and progressive tumors, have to comprise more than one tumor as a minimum prerequisite for carrying out the Anova-test. Thus, the minimum prerequisites for determining the predictive genes are for example two responsive tumors, two no-change tumors, and one progressive tumor, or two responsive tumors, one no-change tumor, and two progressive tumors, or one responsive tumor, two no-change tumors, and two progressive tumors.

The health conditions of the animals used for xenotransplantation in the method according to the present invention is significantly impaired due to tumor growth. Accordingly, the life span of the test animals used for xenotransplantation in the method of the present invention is significantly shortened when compared to test animals not used in the method of the present invention. Therefore, the test animals either are sacrified early due to large tumor burden of the xenotransplanted tumor material or are killed after the completion of the method according to the present invention.

In a preferred embodiment of the present invention step (f) of the above method comprises a step of filtering out the relevant genes before the determination of the predictive genes.

In a further preferred embodiment of the above method step (f) comprises the steps of

-   -   (i) dividing the complete set of gene expression profiles of the         tumor xenografts into sub-sets, each of the sub-sets missing one         of the gene expression profiles,     -   (ii) determining the predictive genes in each sub-set, and     -   (iii) obtaining the gene expression profile being predictive for         the specific response of an individual tumor to the         pharmaceutically effective compound by setting up the         intersection of the predictive genes of all sub-sets.

In this embodiment the step of determining the predictive genes comprises a leave-one-out cross-validation. In k-fold cross-validation, the data is divided into k subsets of (approximately) equal size. The net is trained k times, each time leaving out one of the subsets from training, but using only the omitted subset to compute whatever error criterion is of interest. If k equals the sample size, this is called “leave-one-out” cross-validation.

Determining a list of predictive genes by taking the intersection of the n-gene-lists (each containing the 300 most specific genes), the risk of false positives is minimized due to the fact that “a gene by chance” would have to be a “false positive by chance” in any of the n-gene-lists, being much more improbable than using the procedures of the prior art. The “leave-out-method” of the present invention to get the predictive genes will also lead to a list of predictive genes, not biased by the tumor later left out in the cross-validation method since each gene which is only predictive because of a single tumor in the training-set will be discarded by using the intersection of the n-gene-lists.

In addition, combining an Anova test with the Fisher's Exact Test in the process of setting up the n-gene-lists is a promising way to get the 300 most specific genes for every time another tumor is left out.

It should be noted that cross-validation is quite different from the “split-sample” or “hold-out” method that is commonly used. In the split-sample method, only a single subset (the validation set) is used to estimate the generalization error, instead of k different subsets; i.e., there is no “crossing”.

The distinction between cross-validation and split-sample validation is extremely important because cross-validation is markedly superior for small data sets; this fact is demonstrated dramatically by Goutte (1997) in a reply to Zhu and Rohwer (1996). For an insightful discussion of the limitations of cross-validation choice among several learning methods, see Stone (1977).

In a more preferred embodiment of the present invention the expression profile of 300 genes is determined for each sub-set when determining the predictive genes in each sub-set.

In another preferred embodiment of the present invention the gene expression profile is validated by a leave-one-out cross-validation.

The pharmaceutically effective compound according to the present invention can be any pharmaceutically effective compound known in the art and/or commercially available for the treatment and/or prevention of cancerous diseases. This includes pharmaceutically effective compounds containing agents effective for preventing tumor growth and/or metastasis or for reducing tumor size. Examples of such agents are angiogenesis inhibitors, including inhibitors of endothelial cell proliferation, e.g. Angiostatin K1-3, Avastin, Endostatin, Fumagillin, and Minocycline EGFR inhibitors, e.g. Cetuximab, and inhibitors of the biosynthesis of TNF-α, e.g. Thalidomide. Further examples of such agents are DNA intercalators/cross-linkers, e.g. Bleomycin, Chlorambucil, Melphalan and Oxaliplatin, DNA synthesis inhibitors, e.g. Aminopterin, 5-Fluoro-5′-deoxyuridine, 5-Fluorouracil, Gemcitabin, Ganciclovir, and Hydroxyurea, Capecitabin, DNA-RNA transcription regulators, topoisomerase II inhibitors, e.g. Actinomycin D, Daunorubicin, Doxorubicin, and Idarubicin, enzyme inhibitors, e.g. Curcumin, Etoposide, and Trichostatin A, agents causing demethylation of the DNA, e.g. 5-Aza-2′-deoxycytidine and 5-Azacytidine, agents having an antiproliferative effect, e.g. Cholecalciferol, microtubule inhibitors, e.g. Colchicine, Docetaxel, Nocodazole, Paclitaxel, Vinblastine, Vincristine, Vindesine, and Vinorelbin, and apoptosis causing agents, e.g. Troglitazone and Thapsigargin. In a preferred embodiment of the present invention the pharmaceutically effective compound is Avastin, a VEGF inhibitor.

In a more preferred embodiment of the present invention, the pharmaceutically effective compound is Avastin and the human tumor material being xenotransplanted into the test animals is derived from colon, non small cell lung, breast and/or renal tumors.

In a particularly preferred embodiment of the present invention the pharmaceutically effective compound is Avastin and the predictive genes of the gene expression profile obtained by the above method consists of genes characterized by SEQ. ID. No. 1 to SEQ. ID. No. 118.

In another preferred embodiment of the present invention the present invention the pharmaceutically effective compound is Avastin and the predictive genes of the gene expression profile obtained by the above method consists of genes characterized by the sequences shown in Table 3.

It is a further object of the present invention to provide a use of a gene expression profile obtained by the above method in the manufacture of a medicament carrying out an individual, tumor-specific diagnosis or treatment of a cancerous disease.

Another object of the present invention is the provision of a method for predicting the responsiveness of an individual tumor to a treatment with a pharmaceutically effective compound comprising the steps of

-   -   (a) providing a gene expression profile obtained by the above         method,     -   (b) determining the gene expression profile of the tumor to be         treated, and     -   (c) comparing the gene expression profile of step (a) with the         gene expression profile of step (b).

Using the above method it is possible to predict the prospect of success of a treatment of a patient suffering from a cancerous disease. Therefore, the above method can be used to avoid unnecessary treatment with chemotherapeutics which are a great physical and psychological burden on a tumor patient. Thus, the above method is useful for optimizing the individual treatment of a cancerous disease and avoiding the costs and serious side-effects of an ineffective chemotherapy.

In a preferred embodiment of the present invention the gene expression profiles of the tumor to be treated is obtained using microarray techniques.

The present invention also relates to the use of Avastin for a gene expression profile-dependent treatment of a cancerous disease. Avastin may e.g. be used in the treatment of a patient having a tumor, wherein the dosage of Avastin has been lowered or increased depending on the gene expression profile of said tumor when compared to the dosage which would have been used in the treatment of said patient without obtaining the gene expression profile of said tumor. In a preferred embodiment of the present invention, the gene expression profile-dependent treatment of a cancerous disease is a combination therapy comprising the use of at least one other pharmaceutically effective compound. In a more preferred embodiment of the present invention the decision whether Avastin is to be used in said combination therapy is dependent on the gene expression profile of the tumor to be treated. In a most preferred embodiment of the present invention the decision whether Avastin is to be used in said combination therapy is dependent on a gene expression profile consisting of the genes listed above.

The present invention also relates to a microarray, wherein the nucleotide sequences attached to the substrate consist of nucleotide sequences corresponding to the predictive genes of a gene expression profile obtained by the method for providing a gene expression profile being predictive for the specific response of an individual tumor to a pharmaceutically effective compound of the present invention.

The term “microarray” as used herein means any arrangement of biomolecules, such as nucleic acids, antibodies, preferably oligonucleotides in addressable locations on a substrate resulting in a so-called “biochip”. The substrate may be any substrate suitable for use in a microarray known in the art, like e.g. membranes, glass, plastic, silicon wafers, and metal alloys. The information obtained when using microarray techniques can also be obtained by other methods known in the art for determining gene expression profiles, e.g. PCR, Northern-analysis, etc.

It is a further object of the present invention to provide a diagnostic kit containing the above microarray.

The figure shows:

FIG. 1 shows a flowchart which gives an example of a preferred embodiment how the method for providing a gene expression profile being predictive for the specific response of an individual tumor to a pharmaceutically effective compound according to the present invention may be carried out. sd: standard deviation.

FIG. 2 shows an overview of a preferred embodiment how the method for providing a gene expression profile being predictive for the specific response of an individual tumor to Avastin as described in Example 1 may be obtained.

The present invention will now be further illustrated in the following examples without being limited thereto.

EXAMPLES Example 1

The activity of Avastin has been tested against a set of 46 of patient derived tumor xenografts in nude mice derived from different tumor types preferably known to have the chance of being responsive to Avastin e.g. colon, non small cell lung, renal, or breast cancers. The gene expression profiles for the same tumors have been obtained by using the Affymetrix gene-expression Arrays HG-U133A/B and HG-U 133 Plus 2.0. These gene expression arrays determine the expression of about 34,000 genes.

For identifying genes, being predictive for the specific response of an individual tumor to a specific compound, the following steps are carried out, starting with a list of all gene expressions determined by the arrays:

-   (1) Every gene expression that has a value of lower than 0.01 was     set to 0.01 to make natural log transformation for further     statistical analysis possible. -   (2) Every gene expression on a single chip was normalized to the     median of the “not absent” genes being described by Affymetrix as     “positive control genes” to make an inter-chip comparison possible     and eliminate non-biological variances. -   (3) All genes with an “absent” status in all tumor samples were     removed from the list. -   (4) All genes with a standard deviation of greater or equal 0.75 in     at least one of the classification-groups (R, NC, P) were removed     because they are not supposed to be predictive for the groups.

After these “quality filtering” steps the main determination of predictive genes is carried out:

-   (1) The training-set of the 46 tumor samples is divided into 46     sub-training-sets, each of these sub-training-sets missing one,     different tumor. -   (2) A list of 300 genes with the highest classification group     specificity is determined for each sub-training-set.

Each gene in this list has to fulfill the following requirements:

-   -   having a raw signal of at least 30 in at least (46−1)/4 which         equals about 11 tumor samples, and therefore being expressed in         at least ¼ of all tumors above a critical level of background.     -   having a “specificity rank” of ≦300 with the specificity rank         defined by:     -   specificity rank=1/(p-val+1/Fish.Rank) with     -   p-val determined by a Welch ANOVA test across the         classification-groups     -   Fish.Rank determined by the Hypergeometric Fisher's Exact Test.

The procedure carried out for all 46 sub-training-sets, results in 46 lists of 300 genes respectively. By setting up a gene-list containing the intersection of all these 300 gene containing lists, the result is a set of genes which were specific in all sub-training-sets and is not dependent on a single tumor sample. This step minimizes the risk of “false positive” genes, which otherwise could have been wrongly identified as being specific/predictive.

The final outcome is a list of 118 gene expression in 46 tumors (Table 1, horizontal: different tumors tested, vertical: Affymetrix genes) which is predictive for the response of these tumors to Avastin. The tumor types used determining said gene profile are shown in Table 2 and the sequences of the predictive genes are shown in Table 3. The gene signature is validated by a “leave-one-out cross-validation” using e.g. either a “k-nearest neighbours” or a “support vector machine” classification algorithm.

After validation, the gene expression profile can be used for further prospective validation or to predict tumor samples with unknown chemosensitivity. Using e.g. a “support vector machine” of order 1 for a “leave-one-out cross-validation” showed that the detected genes have a very good ability to discriminate the tumors into the three classification groups and predict tumor response to Avastin (FIG. 2).

Methods

It should be noticed that k-nearest neighbours and support vector machines are available in the prior art.

A. Welch Anova (Parametric)

Let i index over the G groups formed by distinct levels of the comparison parameter.

Let Xik be the expression values, with k running over the replicates for each situation, interpreted according to the current interpretation (ratio, log of ratio, fold change).

Let:

Ni=the number of non-missing data values for each group,

${\overset{\_}{X}}_{i} = {{1/N_{i}}{\sum\limits_{k - 1}^{N_{i}}\; X_{ik}}}$ be the group means, and

${SS}_{i} = {\sum\limits_{k - 1}^{N_{i}}\;\left( {X_{ik} - {\overset{\_}{X}}_{i}} \right)^{2}}$ be the within-group sum of squares.

In all calculations, missing values (No Data) or (NaN) are left out of the sums, not propagated. If any of the Ni are zero, drop that parameter level from the analysis, and readjust G accordingly. If G is not at least 2, exit (p-value=1).

First, it has to be checked that each group has Ni greater than or equal to 2 and SSi greater than 0. If not, remove it from consideration and recompute G. If G is not at least 2, exit (p-value=1). (This reflects the more stringent requirements of not assuming the variances equal—if the variance estimate is pooled, replicates are only needed for at least one group, if variances are separately estimated then replicates are needed for each group.) Then compute:

$w_{i} = {N_{i}\left( \frac{N_{i} - 1}{{SS}_{i}} \right)}$ the group weights

$W = {\sum\limits_{i - 1}^{G}\; w_{i}}$ the sum of weights

$\overset{\sim}{X} = \frac{\sum\limits_{i - 1}^{G}{w_{i}\;{\overset{\_}{X}}_{i}}}{W}$ the weighted mean

-   -   BSS=Σw_(i)( X_(i) −{tilde over (X)})² the between-groups sum of         squares     -   d₁=G−1 the numerator degrees of freedom     -   BMS=BSS/d₁ the between groups mean square

$Z = {\frac{1}{G^{2} - 1}{\sum\limits_{i = 1}^{G}\;{\left( {1 = \frac{w_{i}}{\overset{\_}{W}}} \right)^{2}/\left( {N_{i} = 1} \right)}}}$

$d_{2} = \frac{1}{3\;\overset{\_}{Z}}$ the denominator degrees of freedom

-   -   if d₂ is not greater than zero, then exit (p-value=1).     -   WMS=1+2(G−2)Z the within-group. mean square     -   W=BMS/WMS the test statistic

The (approximate) p-value is calculated by looking up W in the upper tail probability of an F distribution with d1 and d2 degrees of freedom. Note that d2 will not, in general, be an integer.

B. Fisher's Exact Test:

Fisher's Exact Test looks for an association between expression level and class membership. Each gene is tested for its ability to discriminate between the classes. Genes with the lowest p-values are kept for the subsequent calculations.

In this method, all the measurements for a given gene are ordered according to their normalized expression levels. For each class (parameter value), the predictor places a mark in the list where the relative abundance of the class on one side of the mark is the highest in comparison to the other side of the mark. The genes that are most accurately segregated by these markers are considered to be the most predictive. A list of the most predictive genes is made for each class and an equal number of genes (lowest p-value using Fisher's Exact Test) are taken from each list.

TABLE 1 CXF_975, LXFA_297, LXFE_409, LXFL_430, MAXF_1322, MAXF_1384, MAXF_401, CXF_264, Avastin_p Avastin_p Avastin_p LXFA_923, Avastin_p Avastin_p Avastin_p Avastin_p Avastin_p Avastin_p MAXF_583, Avastin_p NC NC NC NC NC NC NC NC NC NC Systematic Name normalized normalized normalized normalized normalized normalized normalized normalized normalized normalized 200076_s_at 0.241 0.199 0.253 0.159 0.169 0.19 0.169 0.193 0.175 0.236 200631_s_at 0.698 0.794 0.426 0.48 0.701 0.285 1.46 0.416 1.151 0.662 201722_s_at 0.0751 0.0723 0.102 0.197 0.0484 0.0508 0.0817 0.0681 0.101 0.0659 201919_at 0.223 0.242 0.265 0.261 0.244 0.184 0.195 0.273 0.242 0.353 202333_s_at 0.0582 0.0986 0.11 0.106 0.0479 0.0527 0.107 0.113 0.0493 0.0931 202758_s_at 0.0953 0.0864 0.0666 0.0295 0.101 0.103 0.0532 0.161 0.0683 0.105 203092_at 0.0634 0.0387 0.0392 0.01 0.0549 0.0703 0.0884 0.0426 0.0422 0.0821 203846_at 0.0428 0.0586 0.0497 0.0426 0.0458 0.0351 0.0704 0.0662 0.0626 0.0748 205042_at 0.0707 0.198 0.0601 0.0437 0.0641 0.039 0.01 0.0433 0.0542 0.0759 205046_at 0.0873 0.0218 0.034 0.0273 0.0488 0.041 0.0605 0.0452 0.0746 0.0492 205105_at 0.0537 0.117 0.0693 0.0541 0.0305 0.01 0.0432 0.0369 0.01 0.0256 205481_at 0.01 0.01 0.01 0.01 0.0248 0.01 0.0558 0.0255 0.0443 0.0596 206003_at 0.0311 0.01 0.01 0.01 0.0423 0.01 0.01 0.01 0.0239 0.01 208369_s_at 0.0444 0.0288 0.0353 0.0372 0.0571 0.0312 0.0784 0.0426 0.0225 0.045 208848_at 0.0517 0.0678 0.0562 0.0683 0.078 0.0488 0.0458 0.0592 0.0218 0.0424 208951_at 0.0759 0.0819 0.0431 0.0869 0.0946 0.0839 0.0764 0.101 0.0788 0.186 209161_at 0.122 0.097 0.0784 0.0574 0.114 0.0898 0.205 0.0916 0.27 0.101 209758_s_at 0.01 0.01 0.0222 0.0246 0.01 0.01 0.01 0.01 0.01 0.01 211974_x_at 0.235 0.249 0.278 0.297 0.216 0.236 0.325 0.256 0.373 0.243 211976_at 0.063 0.162 0.0588 0.167 0.13 0.162 0.0784 0.0363 0.157 0.105 212394_at 0.0242 0.01 0.01 0.0241 0.01 0.0215 0.01 0.01 0.01 0.01 213677_s_at 0.0848 0.107 0.0849 0.116 0.14 0.0918 0.163 0.183 0.167 0.179 214086_s_at 0.0792 0.0362 0.0876 0.0782 0.0736 0.0859 0.0751 0.171 0.109 0.21 214585_s_at 0.0913 0.133 0.247 0.178 0.189 0.135 0.161 0.115 0.196 0.17 214672_at 0.044 0.0448 0.0771 0.0481 0.0893 0.0703 0.0751 0.0675 0.0845 0.0973 214844_s_at 0.01 0.01 0.0967 0.01 0.0231 0.0293 0.391 0.118 0.0366 0.0371 217797_at 0.207 0.554 0.947 0.458 0.422 0.355 0.595 0.458 0.726 0.241 217895_at 0.0917 0.135 0.0954 0.113 0.124 0.123 0.095 0.122 0.0823 0.137 218625_at 0.0574 0.222 0.0222 0.01 0.01 0.0332 0.118 0.01 0.0683 0.0439 218768_at 0.253 0.155 0.169 0.223 0.304 0.289 0.174 0.148 0.371 0.545 218818_at 0.01 0.01 0.0287 0.01 0.01 0.01 0.0226 0.0248 0.01 0.01 218998_at 0.0957 0.156 0.0745 0.059 0.0937 0.0605 0.15 0.0757 0.0992 0.207 219595_at 0.0319 0.0326 0.0484 0.0317 0.0532 0.0527 0.0332 0.0344 0.0324 0.0957 219906_at 0.0372 0.0509 0.0366 0.0339 0.0309 0.0351 0.0292 0.0331 0.0514 0.0633 221214_s_at 0.0469 0.0362 0.0209 0.0241 0.0427 0.0293 0.0485 0.0255 0.0471 0.0434 221249_s_at 0.038 0.0774 0.0849 0.064 0.261 0.0781 0.0578 0.0993 0.0317 0.0717 222587_s_at 0.0831 0.0866 0.143 0.062 0.0315 0.0293 0.0233 0.0244 0.0305 0.01 222612_at 0.0212 0.0881 0.042 0.101 0.0722 0.0976 0.0934 0.0952 0.0722 0.156 222775_s_at 0.0993 0.104 0.106 0.121 0.0848 0.137 0.0989 0.0893 0.175 0.103 222807_at 0.0254 0.0697 0.0395 0.0784 0.0951 0.0781 0.0975 0.0685 0.101 0.122 222906_at 0.154 0.131 0.17 0.126 0.246 0.169 0.211 0.217 0.249 0.133 223175_s_at 0.0882 0.0637 0.0642 0.0767 0.111 0.0846 0.0687 0.0673 0.13 0.0861 223197_s_at 0.194 0.194 0.0913 0.22 0.117 0.111 0.187 0.149 0.127 0.17 223206_s_at 0.264 0.22 0.178 0.127 0.198 0.163 0.187 0.171 0.109 0.169 223448_x_at 0.373 0.247 0.183 0.193 0.214 0.416 0.184 0.209 0.214 0.349 223470_at 0.0942 0.182 0.18 0.145 0.0853 0.0911 0.169 0.327 0.181 0.225 223518_at 0.0823 0.0816 0.0938 0.105 0.115 0.14 0.0934 0.11 0.0844 0.112 223528_s_at 0.109 0.109 0.197 0.251 0.157 0.296 0.159 0.233 0.176 0.239 223570_at 0.0526 0.0329 0.0518 0.0457 0.134 0.0976 0.0947 0.109 0.0722 0.122 224473_x_at 0.1 0.1 0.133 0.107 0.159 0.202 0.0769 0.128 0.16 0.132 224721_at 0.135 0.0996 0.151 0.151 0.0962 0.322 0.122 0.19 0.156 0.228 225025_at 0.0942 0.0916 0.114 0.0936 0.0796 0.15 0.0769 0.0777 0.127 0.0738 225097_at 0.0509 0.101 0.111 0.0502 0.0825 0.0813 0.325 0.366 0.0742 0.209 225506_at 0.193 0.0966 0.153 0.118 0.132 0.12 0.13 0.0986 0.215 0.118 225554_s_at 0.246 0.272 0.43 0.297 0.407 0.475 0.254 0.263 0.419 0.436 225584_at 0.0517 0.0548 0.0617 0.0671 0.0613 0.0456 0.0536 0.0383 0.0539 0.0634 225841_at 0.266 0.2 0.563 0.245 0.325 0.244 0.133 0.209 0.103 0.295 225947_at 0.516 0.434 0.434 0.453 0.563 0.394 0.389 0.256 0.371 0.517 226124_at 0.138 0.132 0.202 0.129 0.0739 0.124 0.115 0.157 0.13 0.205 226139_at 0.0577 0.0692 0.0592 0.0632 0.0567 0.0651 0.0577 0.0847 0.0824 0.0634 226308_at 0.0509 0.0229 0.0222 0.01 0.0928 0.0423 0.0604 0.0348 0.0478 0.0918 226428_at 0.154 0.107 0.123 0.0575 0.245 0.133 0.132 0.169 0.176 0.276 226616_s_at 0.479 0.389 0.432 0.608 0.419 0.452 0.312 0.202 0.369 0.397 226651_at 0.0679 0.0324 0.0247 0.122 0.0309 0.0911 0.144 0.173 0.151 0.127 226693_at 0.115 0.0901 0.131 0.142 0.121 0.0813 0.0879 0.216 0.127 0.158 226749_at 0.173 0.193 0.432 0.251 0.204 0.29 0.162 0.194 0.377 0.29 226810_at 0.117 0.148 0.0913 0.0688 1.081 0.0618 1.545 0.634 0.934 1.86 226839_at 0.129 0.144 0.104 0.0665 0.171 0.133 0.147 0.152 0.149 0.144 226917_s_at 0.288 0.367 0.333 0.385 0.197 0.673 0.441 0.375 0.419 0.306 227181_at 0.0509 0.0488 0.0617 0.0632 0.0573 0.0878 0.135 0.087 0.15 0.195 227412_at 0.078 0.0582 0.0889 0.0293 0.0704 0.0521 0.0426 0.0928 0.0956 0.123 227427_at 0.0365 0.0219 0.0296 0.0242 0.0366 0.0748 0.0302 0.029 0.131 0.0322 227472_at 0.0322 0.0363 0.0518 0.0344 0.0292 0.0423 0.01 0.0244 0.0376 0.0322 227603_at 0.084 0.365 0.16 0.0885 0.145 0.277 0.305 0.194 0.167 0.426 227810_at 0.148 0.22 0.141 0.151 0.175 0.0878 0.15 0.0859 0.135 0.212 227921_at 0.268 0.308 0.118 0.066 0.238 0.208 0.288 0.393 0.672 0.541 228286_at 0.0509 0.0587 0.0592 0.0541 0.059 0.0553 0.0687 0.0569 0.0793 0.0871 228650_at 0.102 0.134 0.146 0.104 0.114 0.221 0.0961 0.178 0.19 0.168 228736_at 0.0458 0.0488 0.01 0.0265 0.01 0.0228 0.0275 0.0232 0.0264 0.01 228930_at 0.0993 0.191 0.079 0.216 0.142 0.153 0.113 0.124 0.117 0.11 229001_at 0.0763 0.0483 0.0518 0.01 0.0567 0.0488 0.0426 0.175 0.0885 0.19 229035_s_at 0.111 0.172 0.126 0.121 0.0773 0.114 0.146 0.121 0.162 0.135 229384_at 0.101 0.115 0.0839 0.0806 0.0744 0.0846 0.173 0.0708 0.114 0.151 229421_s_at 0.01 0.01 0.042 0.01 0.01 0.0228 0.0261 0.01 0.01 0.01 229534_at 0.0789 0.0244 0.136 0.0722 0.0344 0.0553 0.0247 0.0209 0.0437 0.0303 229570_at 0.039 0.0448 0.0543 0.0288 0.0304 0.01 0.0288 0.0534 0.0874 0.0303 230048_at 0.01 0.01 0.01 0.01 0.0223 0.0228 0.0302 0.01 0.01 0.01 230791_at 0.118 0.144 0.01 0.0316 0.404 0.0456 2.72 1.519 0.215 0.775 230922_x_at 0.0314 0.0388 0.037 0.0276 0.0412 0.039 0.0522 0.0336 0.0417 0.0454 230983_at 0.0288 0.0314 0.0272 0.0276 0.0229 0.0325 0.0302 0.0313 0.01 0.0275 231271_x_at 0.197 0.196 0.22 0.203 0.287 0.238 0.255 0.328 0.24 0.287 232524_x_at 0.221 0.316 0.353 0.289 0.162 0.446 0.283 0.308 0.341 0.173 232527_at 0.01 0.0672 0.0666 0.0592 0.0647 0.0586 0.114 0.0812 0.0996 0.0748 233214_at 0.146 0.194 0.114 0.109 0.114 0.107 0.119 0.153 0.165 0.0559 233302_at 0.0246 0.0677 0.0222 0.0209 0.083 0.0358 0.01 0.123 0.01 0.0511 233429_at 0.01 0.0334 0.0321 0.0383 0.0309 0.0325 0.0247 0.0278 0.0386 0.0303 233440_at 0.0373 0.0418 0.0296 0.0361 0.0613 0.0488 0.0522 0.0685 0.0458 0.0322 233493_at 0.0212 0.0264 0.0247 0.01 0.01 0.01 0.0233 0.0267 0.0244 0.01 233599_at 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 234735_s_at 0.114 0.104 0.188 0.0795 0.145 0.111 0.092 0.171 0.198 0.114 235363_at 0.0619 0.0682 0.0247 0.044 0.138 0.0846 0.194 0.0777 0.13 0.206 235467_s_at 0.01 0.0279 0.042 0.0265 0.0767 0.0325 0.0453 0.029 0.0407 0.0426 235634_at 0.0339 0.0353 0.0444 0.0412 0.0401 0.0748 0.0343 0.0453 0.0386 0.0322 236312_at 0.0696 0.0568 0.01 0.0231 0.0452 0.0325 0.0934 0.029 0.0712 0.0303 236875_at 0.01 0.01 0.0222 0.01 0.0212 0.0228 0.022 0.01 0.0224 0.01 237023_at 0.0322 0.0548 0.0395 0.0502 0.0401 0.0488 0.0481 0.0441 0.0702 0.0398 239496_at 0.01 0.0358 0.0222 0.0564 0.0355 0.0456 0.081 0.0801 0.0681 0.127 240130_at 0.01 0.01 0.0346 0.0231 0.0206 0.0293 0.022 0.0209 0.0224 0.01 241395_at 0.0424 0.0468 0.0346 0.0355 0.0281 0.0553 0.0549 0.0302 0.0376 0.0483 242171_at 0.0254 0.01 0.01 0.01 0.0435 0.0358 0.081 0.0383 0.0427 0.0549 242602_x_at 0.0543 0.0617 0.0592 0.0519 0.0687 0.0618 0.0728 0.0313 0.0824 0.0682 242606_at 0.0509 0.0363 0.037 0.0333 0.01 0.026 0.01 0.022 0.01 0.01 243003_at 0.0611 0.113 0.0617 0.156 0.131 0.12 0.141 0.168 0.108 0.224 243185_at 0.0229 0.0428 0.01 0.0242 0.01 0.039 0.01 0.01 0.01 0.01 31826_at 0.0715 0.0701 0.115 0.0634 0.0767 0.0625 0.146 0.0866 0.0795 0.0895 35150_at 0.0388 0.0461 0.0653 0.0601 0.0898 0.0527 0.0458 0.0261 0.0303 0.0398 64474_g_at 0.0816 0.0602 0.0274 0.0317 0.058 0.0332 0.0299 0.0795 0.0239 0.046 91617_at 0.0436 0.0387 0.01 0.0388 0.0471 0.0898 0.0472 0.0433 0.0422 0.0576 MAXF_MX1, Avastin_p RXF_1393, Avastin_p CXF_1044, CXF_1753, CXF_1784, CXF_280, CXF_609, CXF_676, CXF_94LX, NC NC Avastin_p P Avastin_p P Avastin_p P Avastin_p P Avastin_p P Avastin_p P Avastin_p P LXFA_1012, Avastin_p P Systematic Name normalized normalized normalized normalized normalized normalized normalized normalized normalized normalized 200076_s_at 0.179 0.212 0.0712 0.132 0.104 0.177 0.153 0.0847 0.142 0.102 200631_s_at 0.664 0.227 0.573 0.753 0.571 0.954 0.495 0.611 0.727 0.653 201722_s_at 0.0975 0.076 0.18 0.216 0.147 0.15 0.349 0.169 0.16 0.301 201919_at 0.222 0.404 0.25 0.303 0.214 0.213 0.203 0.234 0.261 0.213 202333_s_at 0.0499 0.105 0.319 0.138 0.293 0.0834 0.126 0.371 0.0787 0.333 202758_s_at 0.0983 0.0962 0.0582 0.0463 0.0672 0.055 0.0406 0.0635 0.0416 0.0428 203092_at 0.0735 0.0414 0.0462 0.0385 0.0318 0.0461 0.0215 0.01 0.0362 0.0358 203846_at 0.044 0.0523 0.0442 0.0687 0.0448 0.0688 0.0315 0.0375 0.0597 0.0508 205042_at 0.01 0.0743 0.248 0.322 0.124 0.098 0.0832 0.327 0.01 0.117 205046_at 0.0822 0.054 0.01 0.0336 0.0385 0.0357 0.01 0.0317 0.0647 0.0497 205105_at 0.0279 0.0785 0.0874 0.0981 0.0594 0.0469 0.0695 0.18 0.0801 0.0598 205481_at 0.01 0.0397 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 206003_at 0.01 0.0422 0.01 0.01 0.0346 0.0254 0.01 0.0318 0.024 0.139 208369_s_at 0.0574 0.0641 0.0238 0.0336 0.0291 0.01 0.0272 0.01 0.0258 0.01 208848_at 0.0425 0.113 0.0398 0.0764 0.165 0.0277 0.0413 0.0586 0.0547 0.0554 208951_at 0.116 0.105 0.0391 0.0708 0.0508 0.035 0.0289 0.0672 0.052 0.14 209161_at 0.081 0.043 0.0754 0.0939 0.138 0.137 0.0591 0.0698 0.0968 0.128 209758_s_at 0.01 0.0338 0.0258 0.0231 0.01 0.01 0.01 0.01 0.01 0.0265 211974_x_at 0.131 0.44 0.0987 0.407 0.149 0.14 0.171 0.179 0.204 0.114 211976_at 0.0967 0.12 0.0933 0.144 0.132 0.129 0.106 0.155 0.199 0.177 212394_at 0.01 0.0287 0.01 0.0224 0.01 0.01 0.01 0.0202 0.01 0.01 213677_s_at 0.0936 0.17 0.113 0.0967 0.171 0.0596 0.0382 0.0698 0.108 0.0926 214086_s_at 0.0688 0.0903 0.0466 0.101 0.0671 0.0496 0.0346 0.0374 0.0611 0.172 214585_s_at 0.092 0.231 0.143 0.245 0.181 0.0969 0.123 0.221 0.117 0.177 214672_at 0.0786 0.0911 0.0483 0.0729 0.0532 0.0415 0.0661 0.0587 0.062 0.0453 214844_s_at 0.202 0.149 0.01 0.01 0.01 0.01 0.01 0.01 0.0262 0.022 217797_at 0.38 0.341 0.279 0.237 0.42 0.477 0.328 0.457 0.371 0.594 217895_at 0.0877 0.104 0.152 0.197 0.191 0.12 0.053 0.112 0.131 0.111 218625_at 0.121 0.0945 0.01 0.0904 0.01 0.01 0.01 0.01 0.01 0.01 218768_at 0.169 0.349 0.18 0.297 0.214 0.249 0.138 0.181 0.201 0.187 218818_at 0.0204 0.01 0.0218 0.01 0.0207 0.01 0.01 0.021 0.01 0.01 218998_at 0.0464 0.129 0.0973 0.0974 0.13 0.12 0.0936 0.0976 0.0737 0.115 219595_at 0.0248 0.13 0.0417 0.0624 0.0387 0.0361 0.0292 0.0381 0.0299 0.0412 219906_at 0.0358 0.0295 0.01 0.0582 0.01 0.01 0.0453 0.01 0.0357 0.01 221214_s_at 0.0311 0.0321 0.0626 0.0715 0.0524 0.131 0.0336 0.0774 0.0321 0.0659 221249_s_at 0.0311 0.0397 0.0573 0.0876 0.0463 0.03 0.0208 0.0464 0.0204 0.052 222587_s_at 0.0269 0.0587 0.107 0.1 0.125 0.038 0.0679 0.171 0.0964 0.116 222612_at 0.0665 0.0543 0.0248 0.0626 0.0284 0.01 0.041 0.0314 0.0716 0.0343 222775_s_at 0.146 0.0925 0.0692 0.185 0.0603 0.116 0.103 0.0604 0.164 0.0764 222807_at 0.0616 0.0822 0.0245 0.0496 0.0358 0.01 0.0314 0.033 0.0482 0.0396 222906_at 0.178 0.129 0.0505 0.117 0.0891 0.1 0.0865 0.0572 0.343 0.0547 223175_s_at 0.0856 0.0866 0.05 0.0637 0.0469 0.0814 0.0474 0.0446 0.0533 0.0682 223197_s_at 0.188 0.22 0.0553 0.11 0.0878 0.103 0.115 0.0591 0.163 0.0748 223206_s_at 0.168 0.156 0.0562 0.0921 0.103 0.109 0.122 0.108 0.128 0.0757 223448_x_at 0.447 0.185 0.0814 0.197 0.0749 0.308 0.176 0.0615 0.33 0.0915 223470_at 0.206 0.113 0.0653 0.0992 0.0876 0.0993 0.0474 0.128 0.143 0.108 223518_at 0.0998 0.113 0.0372 0.113 0.0284 0.0803 0.0455 0.0278 0.0628 0.0247 223528_s_at 0.29 0.358 0.0481 0.22 0.0266 0.133 0.22 0.0454 0.0621 0.0745 223570_at 0.0722 0.0778 0.01 0.0212 0.0375 0.0814 0.01 0.01 0.0285 0.0613 224473_x_at 0.126 0.11 0.037 0.0519 0.0587 0.0888 0.082 0.042 0.0694 0.0434 224721_at 0.0835 0.181 0.104 0.13 0.144 0.0676 0.0769 0.0837 0.121 0.103 225025_at 0.199 0.0939 0.0289 0.0437 0.0268 0.0655 0.0948 0.0461 0.0606 0.0512 225097_at 0.075 0.506 0.0851 0.15 0.01 0.01 0.0512 0.01 0.17 0.0776 225506_at 0.201 0.114 0.0457 0.146 0.0392 0.146 0.0673 0.0426 0.117 0.0228 225554_s_at 0.289 0.339 0.112 0.313 0.109 0.448 0.209 0.0623 0.239 0.164 225584_at 0.041 0.0572 0.0471 0.0531 0.0577 0.0201 0.0461 0.044 0.046 0.034 225841_at 0.417 0.0382 0.0787 0.0744 0.13 0.0951 0.111 0.0803 0.127 0.0226 225947_at 0.346 0.339 0.0669 0.351 0.108 0.348 0.214 0.0714 0.379 0.151 226124_at 0.206 0.208 0.0385 0.117 0.0358 0.0613 0.0929 0.0274 0.113 0.0497 226139_at 0.0792 0.0294 0.01 0.0425 0.01 0.0497 0.0493 0.01 0.0248 0.0249 226308_at 0.0396 0.0205 0.01 0.0201 0.01 0.0317 0.01 0.01 0.01 0.0206 226428_at 0.228 0.116 0.0543 0.102 0.0392 0.185 0.0813 0.0436 0.0921 0.0272 226616_s_at 0.304 0.324 0.164 0.269 0.0942 0.224 0.154 0.114 0.346 0.192 226651_at 0.075 0.112 0.0223 0.0685 0.0618 0.0581 0.01 0.0204 0.0818 0.03 226693_at 0.16 0.364 0.0476 0.111 0.0384 0.0793 0.0788 0.0837 0.11 0.0752 226749_at 0.195 0.17 0.0976 0.263 0.137 0.17 0.0941 0.0783 0.181 0.0885 226810_at 0.606 0.451 0.0218 0.0531 0.0407 0.038 0.025 0.01 0.01 0.143 226839_at 0.201 0.131 0.0535 0.0602 0.0555 0.114 0.0781 0.054 0.095 0.0543 226917_s_at 0.217 0.49 0.0674 0.349 0.123 0.144 0.123 0.101 0.373 0.138 227181_at 0.0545 0.355 0.01 0.059 0.01 0.0877 0.0423 0.01 0.107 0.0281 227412_at 0.0934 0.0881 0.0231 0.0602 0.01 0.0465 0.111 0.022 0.104 0.021 227427_at 0.0764 0.0763 0.01 0.01 0.01 0.0275 0.01 0.01 0.01 0.01 227472_at 0.0333 0.0338 0.01 0.0295 0.01 0.0222 0.01 0.01 0.0227 0.01 227603_at 0.155 0.216 0.0252 0.117 0.0282 0.111 0.0897 0.0486 0.0782 0.0436 227810_at 0.103 0.0528 0.0732 0.166 0.0777 0.074 0.113 0.0838 0.17 0.143 227921_at 0.299 0.414 0.0267 0.184 0.188 0.159 0.103 0.0515 0.207 0.111 228286_at 0.0842 0.0998 0.0385 0.0767 0.0617 0.0232 0.0224 0.0392 0.138 0.0577 228650_at 0.0651 0.134 0.0824 0.0767 0.05 0.074 0.0269 0.0401 0.18 0.0793 228736_at 0.0297 0.0543 0.01 0.0224 0.01 0.01 0.0282 0.01 0.0263 0.0216 228930_at 0.117 0.122 0.0303 0.0779 0.0298 0.0655 0.0865 0.0212 0.129 0.069 229001_at 0.111 0.0954 0.01 0.0755 0.01 0.01 0.113 0.0359 0.057 0.01 229035_s_at 0.0807 0.135 0.01 0.116 0.037 0.0919 0.073 0.0335 0.172 0.0539 229384_at 0.087 0.156 0.0219 0.116 0.0293 0.0676 0.101 0.0409 0.11 0.0229 229421_s_at 0.01 0.01 0.01 0.0331 0.01 0.0285 0.01 0.01 0.0212 0.01 229534_at 0.0736 0.0455 0.026 0.0295 0.0222 0.0338 0.01 0.01 0.0278 0.0396 229570_at 0.0439 0.0426 0.01 0.01 0.01 0.0243 0.01 0.01 0.0431 0.01 230048_at 0.01 0.01 0.0212 0.0236 0.01 0.0275 0.0423 0.0322 0.0263 0.0211 230791_at 0.313 0.294 0.01 0.0862 0.0245 0.0486 0.124 0.0428 0.0716 0.0743 230922_x_at 0.01 0.0866 0.0208 0.0519 0.034 0.0476 0.01 0.0241 0.0351 0.0309 230983_at 0.0219 0.0249 0.01 0.01 0.01 0.0444 0.01 0.01 0.0409 0.01 231271_x_at 0.158 0.415 0.0486 0.264 0.0925 0.0856 0.125 0.0874 0.184 0.0659 232524_x_at 0.232 0.217 0.059 0.184 0.12 0.0909 0.101 0.0974 0.226 0.126 232527_at 0.142 0.0895 0.0253 0.0685 0.01 0.0317 0.0762 0.0224 0.111 0.0239 233214_at 0.0877 0.123 0.0493 0.0992 0.0597 0.0623 0.0813 0.0338 0.0921 0.0429 233302_at 0.0899 0.0352 0.01 0.0909 0.01 0.0402 0.01 0.0208 0.103 0.01 233429_at 0.0241 0.069 0.01 0.0271 0.01 0.01 0.0205 0.01 0.0256 0.01 233440_at 0.01 0.0661 0.01 0.0543 0.01 0.0243 0.01 0.01 0.01 0.0238 233493_at 0.01 0.0396 0.01 0.01 0.01 0.01 0.0211 0.01 0.01 0.01 233599_at 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 234735_s_at 0.171 0.0939 0.01 0.01 0.037 0.0782 0.089 0.0486 0.0979 0.0394 235363_at 0.0828 0.0675 0.0249 0.0449 0.0374 0.056 0.01 0.0311 0.076 0.0349 235467_s_at 0.0538 0.0294 0.01 0.0224 0.01 0.0243 0.01 0.01 0.01 0.01 235634_at 0.0311 0.091 0.01 0.0248 0.01 0.0232 0.0256 0.01 0.0256 0.01 236312_at 0.0453 0.0382 0.0202 0.0449 0.0428 0.01 0.0288 0.0366 0.0913 0.01 236875_at 0.0233 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 237023_at 0.0403 0.0499 0.0242 0.0389 0.0233 0.038 0.0333 0.01 0.0365 0.01 239496_at 0.0318 0.0499 0.01 0.0283 0.01 0.0285 0.01 0.01 0.0212 0.01 240130_at 0.01 0.0235 0.01 0.01 0.01 0.0275 0.01 0.01 0.01 0.01 241395_at 0.0283 0.01 0.01 0.0283 0.01 0.01 0.0365 0.01 0.0818 0.01 242171_at 0.0389 0.0338 0.01 0.0212 0.01 0.01 0.0224 0.01 0.01 0.01 242602_x_at 0.0736 0.0793 0.0312 0.0496 0.0344 0.0528 0.05 0.0344 0.038 0.0231 242606_at 0.01 0.01 0.01 0.0331 0.01 0.0232 0.01 0.01 0.0658 0.01 243003_at 0.0927 0.144 0.01 0.0968 0.024 0.0539 0.0224 0.01 0.0891 0.0286 243185_at 0.01 0.0352 0.01 0.0354 0.01 0.01 0.0218 0.01 0.01 0.01 31826_at 0.0566 0.106 0.0658 0.0757 0.0545 0.0892 0.0651 0.0817 0.071 0.0535 35150_at 0.0204 0.107 0.045 0.0519 0.0379 0.0503 0.0648 0.0526 0.0416 0.0305 64474_g_at 0.0594 0.0414 0.0618 0.0449 0.0423 0.0427 0.0245 0.0269 0.0393 0.0399 91617_at 0.0448 0.065 0.0399 0.0357 0.0306 0.0354 0.0201 0.0274 0.0561 0.0511 LXFA_526, LXFA_629, LXFA_644, LXFA_737, LXFA_PC14, LXFE_211, MAXF_1162, LXFA_289, Avastin_p Avastin_p LXFA_586, Avastin_p Avastin_p Avastin_p Avastin_p Avastin_p Avastin_p LXFL_529, Avastin_p Avastin_p Systematic Name P normalized P normalized P normalized P normalized P normalized P normalized P normalized P normalized P normalized P normalized 200076_s_at 0.219 0.294 0.149 0.142 0.0549 0.0548 0.137 0.125 0.15 0.0923 200631_s_at 0.637 0.791 0.42 0.456 0.414 0.62 0.843 1.317 0.56 0.626 201722_s_at 0.161 0.102 0.153 0.152 0.48 0.171 0.233 0.146 0.114 0.134 201919_at 0.189 0.152 0.19 0.204 0.114 0.243 0.187 0.143 0.222 0.254 202333_s_at 0.197 0.11 0.2 0.0559 0.297 0.135 0.314 0.135 0.131 0.0825 202758_s_at 0.0568 0.0607 0.01 0.01 0.0653 0.01 0.11 0.0696 0.0401 0.01 203092_at 0.0277 0.0228 0.01 0.01 0.0228 0.01 0.043 0.04 0.0419 0.0228 203846_at 0.0502 0.0654 0.0639 0.0928 0.0594 0.0523 0.103 0.145 0.0577 0.0393 205042_at 0.296 0.12 0.0433 0.105 0.0992 0.322 0.0489 0.0253 0.123 0.0487 205046_at 0.04 0.0501 0.0274 0.0223 0.061 0.0522 0.0492 0.0662 0.0387 0.0361 205105_at 0.135 0.0392 0.0422 0.0304 0.059 0.0532 0.0622 0.151 0.0525 0.022 205481_at 0.0226 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.0273 0.022 206003_at 0.01 0.0317 0.0239 0.0284 0.0364 0.0722 0.0225 0.01 0.01 0.01 208369_s_at 0.024 0.0296 0.01 0.01 0.0274 0.0227 0.0313 0.0339 0.01 0.0236 208848_at 0.0408 0.0971 0.0901 0.0365 0.0391 0.0495 0.0612 0.208 0.0648 0.0692 208951_at 0.0473 0.0324 0.121 0.0397 0.127 0.0612 0.0688 0.0818 0.0533 0.0479 209161_at 0.116 0.203 0.103 0.113 0.0867 0.0939 0.161 0.25 0.119 0.0786 209758_s_at 0.099 0.401 0.244 0.0276 0.0283 0.0247 0.239 0.01 0.01 0.0919 211974_x_at 0.23 0.208 0.177 0.163 0.14 0.139 0.141 0.212 0.294 0.277 211976_at 0.197 0.0821 0.0479 0.062 0.0609 0.0868 0.0858 0.123 0.101 0.101 212394_at 0.01 0.0327 0.01 0.01 0.0209 0.01 0.0312 0.01 0.0273 0.01 213677_s_at 0.0648 0.0883 0.0821 0.077 0.169 0.117 0.0648 0.0421 0.0818 0.0589 214086_s_at 0.0546 0.0382 0.0525 0.0491 0.0638 0.09 0.0453 0.0754 0.046 0.033 214585_s_at 0.182 0.148 0.132 0.206 0.208 0.18 0.165 0.172 0.117 0.166 214672_at 0.0495 0.0429 0.0331 0.0572 0.0511 0.0534 0.0663 0.108 0.0448 0.0542 214844_s_at 0.01 0.01 0.01 0.01 0.01 0.0301 0.01 0.01 0.0217 0.0228 217797_at 0.791 0.214 0.375 0.225 0.915 0.429 0.282 0.331 0.299 0.31 217895_at 0.0801 0.0692 0.0525 0.102 0.0645 0.0829 0.104 0.117 0.118 0.105 218625_at 0.01 0.01 0.0433 0.01 0.01 0.01 0.01 0.237 0.01 0.01 218768_at 0.245 0.18 0.173 0.238 0.175 0.165 0.214 0.222 0.213 0.123 218818_at 0.01 0.01 0.0228 0.0247 0.0238 0.0291 0.0325 0.0311 0.01 0.0251 218998_at 0.124 0.128 0.115 0.11 0.0416 0.0487 0.124 0.0983 0.0894 0.0432 219595_at 0.0408 0.0314 0.0388 0.0357 0.02 0.0457 0.0634 0.0522 0.0407 0.0369 219906_at 0.0335 0.01 0.0308 0.0247 0.01 0.01 0.01 0.0363 0.046 0.0283 221214_s_at 0.0524 0.0702 0.01 0.0361 0.0287 0.0562 0.118 0.0644 0.022 0.0566 221249_s_at 0.0255 0.0286 0.0365 0.01 0.0217 0.0435 0.021 0.0577 0.0542 0.01 222587_s_at 0.152 0.116 0.0658 0.132 0.132 0.069 0.103 0.0412 0.0398 0.0373 222612_at 0.0506 0.0359 0.0279 0.0476 0.0312 0.0317 0.0246 0.0443 0.0628 0.0607 222775_s_at 0.106 0.0837 0.0918 0.0717 0.0513 0.0773 0.0399 0.0734 0.0852 0.0835 222807_at 0.0594 0.0341 0.0499 0.0456 0.0286 0.0337 0.0419 0.0398 0.0359 0.0451 222906_at 1.034 0.0527 0.271 0.0938 0.114 0.0301 0.0346 0.127 0.225 0.139 223175_s_at 0.091 0.0607 0.0479 0.0664 0.0407 0.0547 0.0359 0.0519 0.0449 0.102 223197_s_at 0.125 0.169 0.154 0.126 0.0618 0.0621 0.056 0.148 0.149 0.117 223206_s_at 0.143 0.109 0.01 0.133 0.0472 0.0894 0.117 0.144 0.1 0.148 223448_x_at 0.091 0.144 0.13 0.158 0.0614 0.0561 0.0906 0.159 0.169 0.216 223470_at 0.107 0.0611 0.0938 0.0871 0.139 0.111 0.0616 0.373 0.0516 0.118 223518_at 0.0695 0.109 0.0698 0.0757 0.0433 0.0357 0.0206 0.0774 0.11 0.0487 223528_s_at 0.0809 0.0616 0.0639 0.149 0.0544 0.121 0.0476 0.0465 0.104 0.154 223570_at 0.0544 0.0235 0.0359 0.0369 0.01 0.0459 0.0368 0.0528 0.0348 0.0607 224473_x_at 0.0948 0.0372 0.0958 0.0905 0.043 0.0598 0.0444 0.0769 0.11 0.154 224721_at 0.14 0.147 0.0738 0.145 0.0724 0.101 0.045 0.0479 0.0937 0.0613 225025_at 0.147 0.0616 0.13 0.114 0.0227 0.0538 0.0412 0.119 0.0684 0.103 225097_at 0.0278 0.0492 0.0279 0.053 0.0663 0.0537 0.0338 0.505 0.0432 0.118 225506_at 0.115 0.0829 0.0798 0.0858 0.078 0.0486 0.0271 0.0783 0.078 0.113 225554_s_at 0.311 0.193 0.164 0.417 0.107 0.165 0.0862 0.301 0.14 0.32 225584_at 0.0518 0.102 0.0539 0.0349 0.0386 0.0489 0.0643 0.0599 0.0667 0.0361 225841_at 0.166 0.114 0.158 0.205 0.139 0.128 0.0755 0.189 0.153 0.159 225947_at 0.513 0.535 0.467 0.469 0.119 0.101 0.103 0.167 0.237 0.238 226124_at 0.105 0.0665 0.0738 0.065 0.0574 0.0338 0.0335 0.127 0.142 0.104 226139_at 0.163 0.0275 0.0698 0.059 0.0285 0.0215 0.01 0.0438 0.0426 0.0715 226308_at 0.0266 0.0235 0.01 0.01 0.01 0.01 0.0226 0.0389 0.01 0.0258 226428_at 0.119 0.157 0.0718 0.0818 0.0471 0.0505 0.038 0.0769 0.0555 0.0811 226616_s_at 0.269 0.343 0.637 0.0938 0.137 0.188 0.0991 0.489 0.313 0.298 226651_at 0.0594 0.0425 0.0658 0.107 0.0718 0.0297 0.0392 0.181 0.165 0.3 226693_at 0.143 0.0341 0.0838 0.0938 0.0636 0.0494 0.045 0.0792 0.0802 0.0805 226749_at 0.161 0.149 0.152 0.153 0.0633 0.15 0.0607 0.201 0.174 0.147 226810_at 0.0455 0.167 0.0439 0.0241 0.0221 0.0688 0.112 0.0573 0.0538 0.157 226839_at 0.148 0.126 0.0639 0.0617 0.0275 0.0564 0.0584 0.0935 0.0634 0.0974 226917_s_at 0.269 0.149 0.251 0.202 0.126 0.135 0.126 0.161 0.234 0.231 227181_at 0.0468 0.051 0.0339 0.0543 0.0283 0.028 0.0211 0.148 0.156 0.132 227412_at 0.01 0.0275 0.02 0.0302 0.01 0.01 0.01 0.0255 0.0303 0.0445 227427_at 0.0228 0.01 0.0319 0.0308 0.01 0.01 0.01 0.01 0.0252 0.0715 227472_at 0.0291 0.0266 0.01 0.0201 0.01 0.01 0.01 0.01 0.01 0.01 227603_at 0.142 0.0301 0.104 0.225 0.01 0.11 0.049 0.123 0.123 0.354 227810_at 0.109 0.0244 0.0798 0.0851 0.0748 0.0647 0.0975 0.0769 0.14 0.0727 227921_at 0.139 0.134 0.257 0.114 0.0305 0.163 0.0244 0.211 0.0308 0.189 228286_at 0.0695 0.0478 0.0479 0.0677 0.0451 0.0417 0.0314 0.0501 0.0297 0.0505 228650_at 0.0923 0.0554 0.156 0.0308 0.0549 0.0485 0.0644 0.177 0.172 0.0631 228736_at 0.01 0.0213 0.01 0.01 0.01 0.01 0.01 0.0206 0.023 0.01 228930_at 0.086 0.093 0.0599 0.0818 0.0235 0.0409 0.0359 0.0778 0.136 0.0986 229001_at 0.0303 0.0399 0.01 0.0282 0.01 0.01 0.01 0.0304 0.01 0.0385 229035_s_at 0.107 0.0961 0.0479 0.103 0.01 0.0727 0.0292 0.0573 0.129 0.0823 229384_at 0.163 0.0744 0.0539 0.065 0.01 0.0224 0.0286 0.0617 0.0852 0.0571 229421_s_at 0.0341 0.01 0.0519 0.01 0.01 0.01 0.01 0.01 0.01 0.01 229534_at 0.0936 0.0319 0.0798 0.109 0.0252 0.193 0.0314 0.0273 0.01 0.0355 229570_at 0.0443 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.0224 0.0337 230048_at 0.01 0.218 0.01 0.01 0.01 0.01 0.0322 0.01 0.0505 0.01 230791_at 0.0632 0.0811 0.01 0.0489 0.0987 0.0331 0.01 0.0322 0.105 0.242 230922_x_at 0.0266 0.0687 0.0399 0.0221 0.0247 0.0295 0.0265 0.025 0.01 0.01 230983_at 0.0594 0.01 0.0339 0.0228 0.01 0.01 0.01 0.0268 0.0325 0.021 231271_x_at 0.234 0.212 0.01 0.134 0.0714 0.109 0.0798 0.244 0.164 0.239 232524_x_at 0.13 0.0771 0.263 0.174 0.11 0.14 0.115 0.128 0.138 0.226 232527_at 0.0455 0.0669 0.0339 0.0429 0.0236 0.0507 0.01 0.089 0.0937 0.0487 233214_at 0.191 0.0846 0.11 0.0858 0.0318 0.0911 0.0204 0.0756 0.0651 0.0673 233302_at 0.0202 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 233429_at 0.0303 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.0337 233440_at 0.0556 0.01 0.0259 0.0308 0.01 0.01 0.01 0.01 0.0247 0.01 233493_at 0.01 0.0253 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 233599_at 0.01 0.01 0.01 0.0248 0.01 0.01 0.01 0.0716 0.01 0.01 234735_s_at 0.11 0.0408 0.0559 0.0697 0.0652 0.036 0.0348 0.0742 0.0566 0.163 235363_at 0.01 0.0594 0.0599 0.0268 0.0386 0.01 0.0451 0.0819 0.01 0.0282 235467_s_at 0.01 0.0332 0.0279 0.0288 0.01 0.01 0.01 0.0268 0.01 0.01 235634_at 0.0544 0.0275 0.0259 0.0248 0.01 0.0209 0.01 0.0389 0.0561 0.0294 236312_at 0.01 0.01 0.0219 0.01 0.01 0.0228 0.01 0.0859 0.0365 0.01 236875_at 0.0354 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 237023_at 0.01 0.0292 0.0299 0.0402 0.01 0.0233 0.01 0.0268 0.01 0.0331 239496_at 0.01 0.01 0.02 0.01 0.01 0.0209 0.01 0.0206 0.0247 0.0481 240130_at 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.0201 0.01 0.01 241395_at 0.0367 0.0337 0.0319 0.01 0.01 0.01 0.01 0.01 0.0286 0.0258 242171_at 0.024 0.0222 0.01 0.0201 0.01 0.0207 0.01 0.0291 0.01 0.0288 242602_x_at 0.0316 0.0372 0.0539 0.065 0.0272 0.0292 0.0289 0.0376 0.0381 0.0469 242606_at 0.01 0.0368 0.01 0.01 0.01 0.01 0.01 0.0201 0.0337 0.0228 243003_at 0.0885 0.01 0.0639 0.0637 0.01 0.0302 0.01 0.105 0.188 0.1 243185_at 0.0518 0.01 0.01 0.0268 0.01 0.01 0.01 0.01 0.01 0.01 31826_at 0.121 0.14 0.108 0.106 0.0565 0.0693 0.123 0.107 0.0993 0.0833 35150_at 0.0844 0.0385 0.0433 0.0397 0.0532 0.0467 0.0746 0.0561 0.0782 0.0644 64474_g_at 0.0429 0.0494 0.0285 0.0353 0.0492 0.0789 0.0593 0.0256 0.0475 0.01 91617_at 0.0604 0.0211 0.01 0.0377 0.0472 0.0771 0.0352 0.0333 0.034 0.0464 MAXF_MCF7, RXF_631, RXF_944LX, CXF_1103, CXF_158, LXFA_592, LXFA_677, Systematic MAXF_449, Avastin_p Avastin_p P RXF_1220, Avastin_p Avastin_p P Avastin_p P Avastin_p R Avastin_p R CXF_1729, Avastin_p Avastin_p R Avastin_p R Name P normalized normalized P normalized normalized normalized normalized normalized R normalized normalized normalized 200076_s_at 0.199 0.142 0.211 0.223 0.18 0.175 0.152 0.146 0.151 0.128 200631_s_at 0.665 0.514 0.698 0.332 1.057 0.846 0.894 0.931 1.04 0.862 201722_s_at 0.133 0.0458 0.141 0.0912 0.0974 0.214 0.103 0.132 0.0719 0.0631 201919_at 0.281 0.176 0.239 0.322 0.461 0.283 0.333 0.305 0.448 0.296 202333_s_at 0.078 0.141 0.131 0.243 0.149 0.0606 0.0889 0.12 0.114 0.133 202758_s_at 0.066 0.053 0.0602 0.0586 0.0617 0.083 0.0718 0.0506 0.0602 0.0212 203092_at 0.0522 0.023 0.055 0.0259 0.0335 0.0925 0.0351 0.0577 0.0886 0.01 203846_at 0.01 0.0495 0.0499 0.01 0.0736 0.0585 0.0658 0.0806 0.0736 0.0763 205042_at 0.145 0.01 0.122 0.0867 0.0822 0.0372 0.0239 0.01 0.0318 0.0252 205046_at 0.0296 0.0288 0.0791 0.0417 0.079 0.067 0.0368 0.0798 0.0435 0.0482 205105_at 0.01 0.0547 0.0653 0.167 0.0487 0.13 0.0919 0.0965 0.0619 0.111 205481_at 0.0407 0.01 0.0997 0.0327 0.01 0.01 0.01 0.01 0.01 0.01 206003_at 0.01 0.0299 0.01 0.0259 0.01 0.0383 0.0274 0.0396 0.0251 0.0321 208369_s_at 0.0837 0.0368 0.0396 0.045 0.0303 0.0489 0.0423 0.0221 0.0619 0.0218 208848_at 0.0434 0.0308 0.129 0.0518 0.0963 0.0702 0.0616 0.0654 0.0652 0.0832 208951_at 0.105 0.122 0.0602 0.0946 0.0768 0.0745 0.0432 0.0424 0.01 0.0545 209161_at 0.0511 0.107 0.0946 0.0484 0.142 0.156 0.106 0.198 0.159 0.234 209758_s_at 0.0687 0.01 0.0224 0.588 0.0206 0.0223 0.01 0.01 0.01 0.01 211974_x_at 0.176 0.226 0.342 0.393 0.253 0.364 0.275 0.483 0.406 0.244 211976_at 0.123 0.0841 0.098 0.0777 0.119 0.117 0.194 0.198 0.268 0.132 212394_at 0.01 0.01 0.0396 0.01 0.0303 0.033 0.0325 0.01 0.0201 0.01 213677_s_at 0.1 0.0616 0.0946 0.08 0.0508 0.0968 0.103 0.139 0.151 0.131 214086_s_at 0.0253 0.0443 0.0516 0.0349 0.093 0.0723 0.0504 0.0438 0.0886 0.0809 214585_s_at 0.162 0.125 0.225 0.227 0.167 0.195 0.2 0.268 0.273 0.292 214672_at 0.0515 0.0875 0.0413 0.0428 0.12 0.0936 0.0667 0.0843 0.0686 0.106 214844_s_at 0.01 0.01 0.0344 0.0203 0.01 0.01 0.01 0.01 0.01 0.01 217797_at 0.405 0.317 0.487 0.467 0.195 0.282 0.24 0.175 0.139 0.169 217895_at 0.126 0.0504 0.115 0.0698 0.0595 0.177 0.162 0.162 0.166 0.11 218625_at 0.01 0.01 0.01 0.01 0.13 0.01 0.0218 0.258 0.0284 0.01 218768_at 0.197 0.214 0.244 0.17 0.115 0.307 0.276 0.237 0.301 0.18 218818_at 0.01 0.01 0.01 0.0664 0.01 0.0468 0.0222 0.0263 0.0284 0.0442 218998_at 0.0223 0.0478 0.105 0.0586 0.0963 0.146 0.151 0.164 0.174 0.147 219595_at 0.0388 0.0423 0.086 0.0518 0.0487 0.0734 0.0598 0.0436 0.0937 0.0539 219906_at 0.01 0.0363 0.01 0.01 0.0227 0.0426 0.0496 0.0407 0.01 0.0252 221214_s_at 0.0453 0.0581 0.0567 0.0462 0.0563 0.149 0.0667 0.0554 0.0652 0.039 221249_s_at 0.0534 0.0279 0.0327 0.0439 0.0249 0.0223 0.0568 0.0936 0.154 0.0258 222587_s_at 0.0337 0.0664 0.234 0.0296 0.0543 0.0572 0.0581 0.104 0.118 0.126 222612_at 0.0902 0.0658 0.0832 0.0355 0.0379 0.0286 0.0342 0.0591 0.0502 0.0222 222775_s_at 0.0791 0.0622 0.0928 0.069 0.0666 0.107 0.0932 0.1 0.133 0.108 222807_at 0.141 0.0514 0.0812 0.0709 0.0728 0.0338 0.0607 0.0353 0.0968 0.0611 222906_at 0.222 0.0329 0.0948 0.0591 0.043 0.0416 0.0983 0.277 0.219 0.0689 223175_s_at 0.0628 0.0526 0.104 0.0631 0.0646 0.101 0.0727 0.0669 0.0788 0.0678 223197_s_at 0.106 0.0454 0.149 0.134 0.137 0.0884 0.121 0.249 0.168 0.202 223206_s_at 0.208 0.239 0.18 0.175 0.161 0.101 0.112 0.0778 0.0968 0.136 223448_x_at 0.396 0.135 0.195 0.331 0.358 0.299 0.262 0.179 0.229 0.396 223470_at 0.144 0.0807 0.0716 0.0729 0.0605 0.0338 0.0804 0.135 0.0824 0.106 223518_at 0.1 0.0622 0.147 0.13 0.129 0.169 0.113 0.0756 0.129 0.09 223528_s_at 0.12 0.142 0.0928 0.152 0.2 0.408 0.152 0.115 0.125 0.101 223570_at 0.0646 0.0323 0.0561 0.0769 0.0441 0.0598 0.0513 0.0444 0.0394 0.0522 224473_x_at 0.105 0.16 0.238 0.0946 0.127 0.159 0.0966 0.0751 0.143 0.0934 224721_at 0.123 0.0604 0.139 0.142 0.139 0.153 0.0821 0.129 0.147 0.211 225025_at 0.224 0.0586 0.0928 0.0729 0.0902 0.0988 0.171 0.0678 0.0287 0.0667 225097_at 0.119 0.0323 0.503 0.13 0.083 0.203 0.1 0.119 0.964 0.17 225506_at 0.201 0.149 0.0754 0.0591 0.0738 0.164 0.158 0.0911 0.122 0.11 225554_s_at 0.242 0.163 0.354 0.179 0.179 0.419 0.307 0.335 0.441 0.269 225584_at 0.0628 0.0442 0.145 0.122 0.112 0.0832 0.0513 0.0952 0.0824 0.0789 225841_at 0.141 0.412 0.0484 0.0414 0.198 0.0338 0.109 0.138 0.0753 0.147 225947_at 0.201 0.184 0.391 0.3 0.307 0.471 0.404 0.435 0.731 0.292 226124_at 0.103 0.139 0.132 0.209 0.122 0.0754 0.0778 0.0856 0.0645 0.113 226139_at 0.0768 0.0681 0.0812 0.0512 0.0379 0.0416 0.0479 0.0536 0.14 0.0378 226308_at 0.0657 0.0263 0.01 0.01 0.01 0.0312 0.0231 0.0284 0.043 0.01 226428_at 0.153 0.0801 0.0658 0.102 0.104 0.237 0.0966 0.132 0.0753 0.0311 226616_s_at 0.236 0.348 0.323 0.327 0.228 0.229 0.174 0.255 0.24 0.377 226651_at 0.0692 0.0777 0.0542 0.0394 0.0451 0.0442 0.01 0.0595 0.0394 0.0456 226693_at 0.107 0.208 0.0793 0.199 0.198 0.117 0.094 0.0971 0.0968 0.0856 226749_at 0.129 0.182 0.114 0.309 0.132 0.185 0.144 0.147 0.219 0.311 226810_at 0.269 0.04 0.104 0.171 0.126 0.01 0.01 0.132 0.136 0.0356 226839_at 0.109 0.112 0.0696 0.142 0.082 0.13 0.0744 0.0966 0.0824 0.0389 226917_s_at 0.229 0.242 0.234 0.209 0.155 0.27 0.204 0.502 0.459 0.182 227181_at 0.0489 0.0377 0.0445 0.0729 0.0451 0.052 0.0633 0.0527 0.0932 0.08 227412_at 0.0442 0.105 0.0367 0.0473 0.0451 0.0936 0.0949 0.055 0.043 0.0511 227427_at 0.0756 0.0562 0.01 0.01 0.0215 0.0416 0.0624 0.0211 0.0466 0.0345 227472_at 0.0349 0.01 0.01 0.01 0.01 0.01 0.0308 0.01 0.01 0.01 227603_at 0.288 0.095 0.112 0.122 0.0687 0.0832 0.0975 0.223 0.129 0.188 227810_at 0.202 0.061 0.132 0.128 0.084 0.143 0.0983 0.167 0.147 0.152 227921_at 0.232 0.15 0.166 0.0808 0.084 0.0936 0.372 0.44 0.0645 0.0222 228286_at 0.0652 0.0383 0.0735 0.01 0.0266 0.0312 0.0496 0.0824 0.1 0.0689 228650_at 0.0657 0.0711 0.172 0.0966 0.0676 0.13 0.0786 0.136 0.165 0.167 228736_at 0.01 0.0233 0.01 0.01 0.0318 0.0286 0.01 0.0591 0.0538 0.0411 228930_at 0.118 0.158 0.0561 0.0847 0.0625 0.0754 0.0769 0.141 0.108 0.138 229001_at 0.01 0.127 0.01 0.01 0.0687 0.0234 0.0821 0.0444 0.0394 0.0289 229035_s_at 0.193 0.0795 0.0793 0.069 0.0933 0.0728 0.1 0.145 0.0788 0.0422 229384_at 0.114 0.0544 0.11 0.0572 0.0543 0.0858 0.119 0.0898 0.125 0.0823 229421_s_at 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.0215 0.02 229534_at 0.01 0.159 0.01 0.0414 0.0943 0.01 0.01 0.0243 0.0358 0.0989 229570_at 0.0233 0.0777 0.01 0.01 0.01 0.01 0.059 0.0215 0.0466 0.0311 230048_at 0.01 0.01 0.0329 0.01 0.01 0.026 0.0265 0.0343 0.0215 0.01 230791_at 0.933 0.0753 0.0677 0.0532 0.0369 0.0364 0.0658 0.0536 0.0896 0.0645 230922_x_at 0.0244 0.01 0.0367 0.0236 0.0277 0.0286 0.0436 0.0398 0.0573 0.0267 230983_at 0.01 0.01 0.0522 0.01 0.0369 0.0338 0.0342 0.0353 0.0323 0.03 231271_x_at 0.26 0.201 0.219 0.152 0.152 0.151 0.166 0.165 0.186 0.177 232524_x_at 0.281 0.231 0.126 0.108 0.11 0.148 0.16 0.432 0.215 0.152 232527_at 0.0361 0.1 0.01 0.0453 0.0451 0.0312 0.0504 0.0774 0.0323 0.04 233214_at 0.0873 0.0885 0.0967 0.0926 0.0615 0.0598 0.0881 0.136 0.129 0.0711 233302_at 0.0477 0.0466 0.01 0.01 0.0236 0.0754 0.0966 0.0696 0.0215 0.01 233429_at 0.01 0.01 0.114 0.0315 0.0246 0.01 0.0368 0.01 0.0215 0.01 233440_at 0.0471 0.0293 0.0232 0.0315 0.0277 0.0754 0.0214 0.0302 0.0573 0.0489 233493_at 0.01 0.01 0.0213 0.01 0.01 0.0208 0.0325 0.027 0.0645 0.0222 233599_at 0.01 0.01 0.01 0.01 0.01 0.01 0.0385 0.0215 0.0215 0.01 234735_s_at 0.196 0.102 0.0696 0.0907 0.0758 0.0442 0.123 0.0357 0.0609 0.0611 235363_at 0.0873 0.052 0.06 0.0611 0.0523 0.0442 0.0521 0.0865 0.0681 0.0734 235467_s_at 0.0605 0.01 0.01 0.01 0.0266 0.0468 0.0256 0.0444 0.01 0.0278 235634_at 0.0221 0.0341 0.0793 0.0631 0.0215 0.0442 0.0333 0.027 0.0251 0.0333 236312_at 0.01 0.01 0.0464 0.01 0.0728 0.039 0.0291 0.0417 0.0466 0.04 236875_at 0.01 0.01 0.029 0.01 0.01 0.01 0.0419 0.01 0.01 0.01 237023_at 0.0273 0.0329 0.0522 0.01 0.042 0.0468 0.0436 0.01 0.0466 0.0489 239496_at 0.0343 0.01 0.01 0.0611 0.0287 0.0338 0.0231 0.0353 0.0358 0.0222 240130_at 0.01 0.01 0.06 0.0296 0.01 0.0234 0.0359 0.0201 0.01 0.01 241395_at 0.039 0.01 0.0271 0.01 0.01 0.0234 0.0222 0.044 0.01 0.01 242171_at 0.0262 0.01 0.01 0.0335 0.0277 0.039 0.0342 0.0302 0.0394 0.0211 242602_x_at 0.0506 0.0544 0.0445 0.0985 0.0543 0.0858 0.0564 0.0545 0.0502 0.0389 242606_at 0.01 0.01 0.0426 0.0355 0.0523 0.026 0.0436 0.0243 0.0466 0.0267 243003_at 0.0873 0.0909 0.0909 0.0769 0.0215 0.0832 0.1 0.145 0.1 0.108 243185_at 0.01 0.0209 0.01 0.01 0.01 0.0208 0.0496 0.0467 0.0538 0.0322 31826_at 0.0346 0.0944 0.115 0.0822 0.144 0.102 0.0966 0.115 0.14 0.135 35150_at 0.0422 0.0297 0.129 0.106 0.0844 0.0606 0.0543 0.0608 0.0886 0.074 64474_g_at 0.0522 0.0489 0.0636 0.0394 0.0757 0.0979 0.0752 0.0438 0.0468 0.0729 91617_at 0.0411 0.0325 0.0413 0.0259 0.0552 0.0585 0.0504 0.045 0.0769 0.062 LXFE_397, LXFE_646, LXFL_1072, MAXF_574, MAXF_857, RXF_393, Systematic Avastin_p R Avastin_p R Avastin_p R Avastin_p R Avastin_p R Avastin_p R Name normalized normalized normalized normalized normalized normalized 200076_s_at 0.155 0.0921 0.142 0.185 0.277 0.294 200631_s_at 1.147 0.725 0.764 0.735 0.676 0.654 201722_s_at 0.125 0.408 0.0518 0.121 0.0265 0.0761 201919_at 0.387 0.392 0.233 0.314 0.188 0.356 202333_s_at 0.103 0.253 0.125 0.684 0.0617 0.131 202758_s_at 0.0632 0.0714 0.0246 0.138 0.0702 0.0562 203092_at 0.0756 0.0472 0.0202 0.105 0.0899 0.0551 203846_at 0.16 0.0786 0.0884 0.0969 0.0514 0.0902 205042_at 0.03 0.0309 0.0567 0.115 0.0428 0.048 205046_at 0.0727 0.0665 0.122 0.0885 0.11 0.0726 205105_at 0.322 0.0613 0.06 0.137 0.0908 0.0609 205481_at 0.01 0.01 0.01 0.01 0.01 0.01 206003_at 0.0355 0.044 0.0333 0.0346 0.0283 0.0246 208369_s_at 0.0436 0.0499 0.0316 0.103 0.0711 0.0375 208848_at 0.244 0.143 0.0775 0.099 0.0796 0.0914 208951_at 0.01 0.01 0.0491 0.143 0.0411 0.0597 209161_at 0.241 0.121 0.149 0.272 0.119 0.11 209758_s_at 0.01 0.01 0.01 0.01 0.01 0.01 211974_x_at 0.337 0.168 0.465 0.228 0.258 0.26 211976_at 0.125 0.125 0.148 0.134 0.184 0.114 212394_at 0.01 0.01 0.01 0.036 0.0214 0.0422 213677_s_at 0.132 0.103 0.0857 0.192 0.0702 0.155 214086_s_at 0.134 0.146 0.0627 0.119 0.0788 0.0668 214585_s_at 0.202 0.191 0.211 0.225 0.168 0.2 214672_at 0.0895 0.0525 0.0567 0.0927 0.11 0.0984 214844_s_at 0.01 0.01 0.01 0.0212 0.0223 0.0363 217797_at 0.114 0.359 0.165 0.543 0.222 0.245 217895_at 0.179 0.158 0.0878 0.227 0.157 0.0879 218625_at 0.383 0.0496 0.01 0.01 0.01 0.0679 218768_at 0.33 0.206 0.282 0.367 0.259 0.185 218818_at 0.0227 0.025 0.01 0.0317 0.03 0.048 218998_at 0.199 0.0789 0.172 0.187 0.0762 0.18 219595_at 0.0562 0.0414 0.0813 0.0523 0.0565 0.0527 219906_at 0.0291 0.01 0.01 0.01 0.01 0.01 221214_s_at 0.0504 0.083 0.024 0.0364 0.0308 0.0633 221249_s_at 0.144 0.121 0.0813 0.0432 0.0839 0.01 222587_s_at 0.0672 0.0588 0.126 0.208 0.0369 0.0556 222612_at 0.0429 0.0252 0.0621 0.0212 0.029 0.0571 222775_s_at 0.109 0.0953 0.0975 0.0795 0.0824 0.0893 222807_at 0.155 0.137 0.045 0.0339 0.0612 0.0864 222906_at 0.186 0.0329 0.0737 0.0339 0.0675 0.0674 223175_s_at 0.0756 0.0715 0.0532 0.0583 0.0926 0.0703 223197_s_at 0.189 0.0907 0.187 0.0805 0.164 0.105 223206_s_at 0.0999 0.127 0.106 0.0941 0.243 0.0615 223448_x_at 0.474 0.124 0.202 0.132 0.228 0.274 223470_at 0.154 0.0811 0.0477 0.0924 0.0997 0.0674 223518_at 0.0928 0.072 0.0805 0.0696 0.194 0.0952 223528_s_at 0.173 0.112 0.115 0.0652 0.4 0.122 223570_at 0.0539 0.0318 0.0648 0.0473 0.0589 0.0615 224473_x_at 0.0787 0.0507 0.0798 0.0488 0.0934 0.195 224721_at 0.145 0.122 0.121 0.131 0.0997 0.173 225025_at 0.0552 0.0467 0.0559 0.0414 0.13 0.0659 225097_at 0.575 0.12 0.111 0.0838 0.294 0.338 225506_at 0.0875 0.0549 0.0996 0.0293 0.199 0.108 225554_s_at 0.417 0.0841 0.4 0.122 0.488 0.164 225584_at 0.0822 0.0494 0.0737 0.0799 0.0424 0.0864 225841_at 0.0747 0.119 0.028 0.156 0.297 0.0322 225947_at 0.285 0.235 0.568 0.365 0.393 0.258 226124_at 0.133 0.0781 0.285 0.0545 0.108 0.0893 226139_at 0.0398 0.01 0.0471 0.0327 0.044 0.0556 226308_at 0.0623 0.0309 0.01 0.038 0.051 0.0322 226428_at 0.123 0.0593 0.0887 0.0492 0.191 0.196 226616_s_at 0.25 0.0476 0.223 0.121 0.247 0.209 226651_at 0.0592 0.035 0.0498 0.0322 0.0267 0.01 226693_at 0.198 0.0926 0.0996 0.0279 0.0864 0.105 226749_at 0.255 0.103 0.207 0.0852 0.196 0.195 226810_at 0.0597 0.354 0.252 0.111 0.0777 0.262 226839_at 0.099 0.0628 0.0662 0.156 0.201 0.11 226917_s_at 0.3 0.119 0.306 0.144 0.298 0.133 227181_at 0.139 0.01 0.0675 0.0694 0.178 0.0586 227412_at 0.0517 0.0245 0.043 0.0306 0.0777 0.0498 227427_at 0.023 0.0238 0.01 0.01 0.0495 0.0366 227472_at 0.023 0.01 0.0259 0.01 0.0534 0.0586 227603_at 0.113 0.0244 0.111 0.0895 0.206 0.101 227810_at 0.175 0.109 0.108 0.144 0.122 0.24 227921_at 0.328 0.0815 0.0934 0.0552 0.188 0.252 228286_at 0.105 0.0706 0.0553 0.0562 0.051 0.063 228650_at 0.211 0.0864 0.117 0.122 0.115 0.0937 228736_at 0.0376 0.043 0.01 0.0268 0.044 0.0264 228930_at 0.099 0.0655 0.0805 0.0624 0.0801 0.0805 229001_at 0.0756 0.0355 0.0409 0.0262 0.0636 0.01 229035_s_at 0.0844 0.0263 0.0675 0.0439 0.168 0.0981 229384_at 0.0999 0.0389 0.0682 0.0469 0.111 0.119 229421_s_at 0.01 0.01 0.01 0.01 0.01 0.01 229534_at 0.0208 0.0232 0.01 0.0217 0.01 0.01 229570_at 0.01 0.01 0.0416 0.01 0.01 0.01 230048_at 0.01 0.0205 0.0218 0.0204 0.022 0.0293 230791_at 0.01 0.01 0.0894 0.0417 0.0636 0.0688 230922_x_at 0.034 0.0296 0.0375 0.0456 0.0408 0.063 230983_at 0.0309 0.0255 0.043 0.134 0.0408 0.0395 231271_x_at 0.155 0.108 0.164 0.0903 0.225 0.0556 232524_x_at 0.247 0.104 0.32 0.16 0.277 0.108 232527_at 0.0517 0.01 0.0477 0.0352 0.0204 0.022 233214_at 0.132 0.03 0.0859 0.0403 0.0958 0.107 233302_at 0.0283 0.0261 0.01 0.02 0.0432 0.01 233429_at 0.01 0.01 0.01 0.01 0.01 0.0205 233440_at 0.0473 0.01 0.06 0.01 0.0314 0.0351 233493_at 0.0217 0.01 0.0246 0.01 0.0204 0.0205 233599_at 0.023 0.0253 0.01 0.01 0.01 0.01 234735_s_at 0.0981 0.0374 0.0477 0.0228 0.118 0.022 235363_at 0.153 0.01 0.0982 0.0953 0.0699 0.0732 235467_s_at 0.01 0.01 0.01 0.0218 0.01 0.0249 235634_at 0.0283 0.01 0.0355 0.023 0.0243 0.0483 236312_at 0.0751 0.047 0.0307 0.029 0.0699 0.0293 236875_at 0.01 0.01 0.01 0.01 0.01 0.01 237023_at 0.0482 0.01 0.0246 0.0257 0.0345 0.0381 239496_at 0.01 0.01 0.0382 0.01 0.0448 0.0542 240130_at 0.01 0.01 0.0232 0.01 0.0212 0.0264 241395_at 0.01 0.01 0.01 0.01 0.022 0.0234 242171_at 0.0371 0.01 0.0259 0.0202 0.0377 0.0249 242602_x_at 0.0407 0.0205 0.0709 0.0684 0.0534 0.0674 242606_at 0.0522 0.0293 0.0239 0.0239 0.0314 0.0337 243003_at 0.0623 0.0216 0.117 0.0249 0.283 0.119 243185_at 0.01 0.01 0.0273 0.01 0.01 0.0293 31826_at 0.101 0.0888 0.0987 0.161 0.0925 0.142 35150_at 0.0645 0.0651 0.0617 0.0868 0.0668 0.108 64474_g_at 0.0792 0.156 0.0366 0.081 0.0625 0.0668 91617_at 0.0523 0.119 0.03 0.0643 0.0668 0.0679

TABLE 2 BXF Bladder cancer CEXF Cancer of the uterine cervix CNXF Cancer of the central nervous system CXF Colon cancer GXF Gastric cancer HNXF Head and neck cancer LEXF Leukemia LXFA Non small cell lung cancer, adeno LXFE Non small cell lung cancer, epidermoid LXFL Non small cell lung cancer, large cell LXFS Small cell lung cancer, LYXF Lymphom cancer MAXF Mammary cancer MEXF Melanoma OEXF Esophageal cancer OVXF Ovarian cancer PAXF Pancreatic cancer PRXF Prostate cancer PXF Pleuramesothelioma RXF Renal cancer SXF Sarcoma TXF Testicular cancer UXF Cancer of the uterine body XF Various histologies HLXF Hodgkin lymphom NLXF Non Hodgkin lymphom

TABLE 3 Organism Probe Common Sequence Set ID Name Description Target Sequence 200076_s_at Human /DEF = Homo sapiens, ccattccagctggagtcgtggggctgggcacaggggaatttttccagagctgagcc (SEQ. ID. No. hypothetical protein tgacgtctgctctgaagaatgcttagaaggttcccagacaccagagccagatgtcc 1) MGC2749, clone cccaccaccggtcaggacctccttgaggtgcacaagcacggtctcctctgagttca MGC:4376, mRNA,  ccccagcccacccccgcacccactaattctgcttttcctgccccttgctccgtaaa complete cds. agtatcaaatactttctccttggtatctcaaggaggtttctgagataggtagaagt /PROD = hypothetical cttgagacggaggctggccatccattcagccctgagcgtgctgagttctgtgtttc protein MGC2749 tctgaatagaggtgtggaacctgaggggccagcaggcctctctgaaggcctccatg gagcaaacggagccacctcgggaaagagtttaatggaatatttttgtacccgatgt ttacagatgctgtt 200631_s_at Human /DEF = Homo sapiens  agacctggtgctctaatgccaagttatacacgggacagttgctggcatgtcttcat (SEQ. ID. No. SET translocation tggctctctaaaatgtggccaagaagataggctctcagtaagaagtctgatggtga 2) (myeloid leukemia- gcagtaactgtccctgctttctggtataaagctctcaaatgtgaccatgtgaatct associated) (SET),  gggtgggataatggactcagctctgtctgctcaatgccattgtgcagagaagcacc mRNA. ctaatgcataagcntaatgctgtaaaatatagtcgctgaaattaaatgccactttt /GEN = SET tcagaggtgaattaatggacagtctggtgaacttcaaaagctttttgatgtataaa /PROD = SET acttgataaatggaactattccatcaataggcaaaagtgtaacaacctatctagat translocation ggatagtatgtaatttctgcacaggtctctgtttagtaaatacatcactgtatacc (myeloid leukemia- gatcaggaatcttgctccaa associated) 201722_s_at Human /DB_XREF = AV692127 attttgattcatctgtgatagtcatggatgcttttattttccttggggtgctgaa (SEQ. ID. No. /CLONE = GKCAOB04 attgagctgaaaaaaaaaggctctttgaatatagttttaatttctctctacagtt 3) ttttttgtttggtttgtgggctgaggaattgtaatttttaattgccttctaaaaa atggaaatttaacaatgtctgatctcagctgaacaaattagatgtttcagttgct cttgggtcaactggcttacagatttacatgtgcacacacacacaaatttcttatc acattttcgacttcttcacttgacctaactgattatgcgaaatacccaagattca tgctactgtaccacagatttgttttcacagcaataaatcttcagttctgttgttt atgattccacttaacaaaaggcctgcagaagtgatttattatttgggtatttgga gataatacatttgatggtatttggaaaacctttttcactccatactcagatatgc ttcattgtcaaatgcatatttagattagattattgaattgtaatgtttatctgct gctttt 201919_at Human /DB_XREF = wp03g05.x1 atccatttcttgcccttcaataattgtccatgcctgccttttgttgtttacatgc (SEQ. ID. No. /CLONE = IMAGE: tcttctgcccagactgttagtaatctagggaccccctttggagctgataagtaca 4) 2463800 gttcagccttttctcctcaaatatataatganctttaacattcctaagaatatag gtatttctgaatgatttaaatttgaggaattttaatacataaaatacaatgtaca aactttctgcccactcagatctcttctccatcatgtacttagtatttcccattaa cctacacactgatttttatgctactccttgtagaaacaaaattctggtttgactc agtttttgtgtttataaacttttggaatgtgtaccccgtttatgtgaag 202333_s_at Human /DB_XREF = wh25c12.x1 ggctcatgcgggatttcaagccttaccagaggacccacctgttgctgtcagtggc (SEQ. ID. No. /CLONE = IMAGE: gcaccatctgaaaacaacatcatgcagtggaatgcagttatatttggaccagaag 5) 2381782 ggacaccttttgaagatggtacttttaaactagtaatagaattttctgaagaata tccaaataaaccaccaactgttaggtttttatccaaaatgtttcatccaaatgtg tatgctgatggtagcatatgtttagatatccttcagaatcgatggagtccaacat atgatgtatcttctatcttaacatcaattcagtctctgctggatgaaccgaatcc taacagtccagccaatagccaggcagcacagctttatcaggaaaacaaacgagaa tatgagaaaagagtttcggccattgttgaacaaagctggaatgattcataataga caactggtctgttaatctttttcatcattgttgtgtataatttacctctcatta 202758_s_at Human /DEF = Homo sapiens gtgacaacctcgtcaacaagccagacgagcgcggcttcacccccctcatctgggc (SEQ. ID. No. regulatory factor ctccgcctttggagagattgagaccgttcgcttcctgctggagtggggtgccgac 6) X-associated ccccacatcctggcaaaagagcgagagagcgccctgtcgctggccagcacaggcg ankyrin-containing gctacacagacattgtggggctgctgctggagcgtgacgtggacatcaacatcta protein (RFXANK), tgattggaatggagggacgccactgctgtacgctgtgcgcgggaaccacgtgaaa mRNA. tgcgttgaggccttgctggcccgaggcgctgacctcaccaccgaagccgactctg /GEN = RFXANK gctacaccccgatggaccttgccgtggccctgggataccggaaagtgca /PROD = regulator y  factor X-associated  ankyrin-containing  protein 203092_at Human /DEF = Homo sapiens  ggcaactccagacctctgggaacaagactgcgggctctgcccccagctctgccag (SEQ. ID. No. putative mitochondrial gacggctgcaagaccagctggcccgggaggggacaacgggctgttgcgggtgcgc 7) inner membrane ggcagctggagacactcccccgcagggccaacccctgccctgttgctctgccctg protein import caggggtcccggcgcatggtcacctggggtgcacacaggtcacacagtgccaaga receptor (hTIM44) ggccccagggcccagggactccccccacagcagggtgggacccgggacccgcggc mRNA, nuclear gene tcagtggcccgctagccacgtcagccaagccactttaggtccattttttaatttt encoding mitochondrial aacagtgctcttccatcttgtgcataagcctgagatttggaaagaataaaacacc protein, complete cds. gaattgcagaaga /GEN = hTIM44 /PROD = putative mitochondrial inner  membrane proteinimport receptor 203846_at Human /DEF = Homo sapiens, tgctccacctttcagtgacatttaagacatcatattcccgtaacattatgtctc (SEQ. ID. No. TAT-INTERACTIVE agtctgatcgtctttaccagtatgaaagtcattcatttagtgctaccaaagggg 8) PROTEIN, 72-KD, clone  atacacaagccctttaggaagcagtacctctcgcctggaggatctgtgccatct MGC: 4116, mRNA,  tggattgagaattgcagatgtgacagaatggattgaccctagttggttggtatt complete cds. gatgacttcagcctggaaattgcttgccttttaaagaagcatatatgggttgga /PROD = TAT- attatgccaaagcataggaagctgggaataagcaaacaaatgctgatatagtca INTERACTIVE gcaaatttggatagtctctagggctcatcatttttcatactacctctctcttct PROTEIN, 72- ggcctgtgtctaaggaattgtacaacataggccagggccaacaaagtggagagg tggacacattttcatgttcattactaaaacaaacagcaaaactattggtttgtt attctgtgttttcctcaagtcagtacatactatttggtttcaggatttctttcc atttctctatcaagcatt 205042_at Human /DEF = Homo sapiens  ttacatttgaactatatccttcctagtgggttagtgtgaaaaagagtttggctg (SEQ. ID. No. UDP-N- attcctaaaactctgccagccctgcagtaatctccaggcctggttattgttcag 9) acetyiglucosamine- acattccatggtgattcctgggaaggaagcttggctgctcagtttctgagtctg 2-epimeraseN- gggtgagataatgttctggaaggacatctgttctttggtgtaatctctcatggt acetylmannosamine  gaaatctgctctgtacatcagacaattgcattgctaccaagtttcataccaa kinase (GNE), mRNA. /GEN = GNE/ PROD = UDP-N- acetyiglucosamine- 2-epimeraseN- acetylmannosamine kinase 205046_at Human /DEF = Homo sapiens aatcagcatctttccaatgaggtcaaaacttggaaggaaagaacccttaaaagag (SEQ. ID. No. centromere protein aggctcacaaacaagtaacttgtgagaattctccaaagtctcctaaagtgactgg 10) E (312 kD) (CENPE), aacagcttctaaaaagaaacaaattacaccctctcaatgcaaggaacggaattta mRNA. caagatcctgtgccaaaggaatcaccaaaatcttgtttttttgatagccgatcaa /GEN = CENPE agtctttaccatcacctcatccagttcgctattttgataactcaagtttaggcct /PROD = centromere ttgtccagaggtgcaaaatgcaggagcagagagtgtggattctcagccaggtcct protein E tggcacgcctcctcaggcaaggatgtgcctgagtgcaaaactcagtagactcctc tttgtcacttctctggagatccagcattccttatttggaaatgactttgtttatg tgtctatccctggtaatgatgttgtagtgcagcttaatttcaattcagtctttac tttgccactag 205105_at Human /DEF = Homo sapiens acttcttctctcatgaatcatccagtcattccaatggcaaataagttctcaccta (SEQ. ID. No. mannosidase, cccttgagctgcaaggtgaattctctccattacagtcatctttgccttgtgacat 11) alpha, class 2A, tcatctggttaatttgagaacaatacagtcaaaggtgggcaatgggcactccaat member 1 (MAN2A1), gaggcagccttgatcctccacagaaaagggtttgattgtcggttctctagcaaag mRNA. gcacagggctgttttgttctactactcagggaaagatattggtacagaaactttt /GEN = MAN2A1 aaacaagtttattgtcgaaagtctcacaccttcatcactatccttgatgcattca /PROD = mannosidase, cctcccggcactcagaatataagtgagatcaacttgagtccaatggaaatcagca alpha, class 2A, cattccgaatccagttgaggtgaacctgactttcacatttggattgagaatcatt member 1 ggcttttatacctttcttggt 205481_at Human /DEF = Homo sapiens gaggagaacactagacatgccaactcgggagcattctgcctgcctgggaacgggg (SEQ. ID. No. adenosine A1 tggacgagggagtgtctgtaaggactcagtgttgactgtaggcgcccctggggtg 12) receptor (ADORA1), ggtttagcaggctgcagcaggcagaggaggagtacccccctgagagcatgtgggg mRNA. gaaggccttgctgtcatgtgaatccctcaatacccctagtatctggctgggtttt /GEN = ADORA1 caggggctttggaagctctgttgcaggtgtccgggggtctaggactttagggatc /PROD = adenosine A1 tgggatctggggaaggaccaacccatgccctgccaagcctggagcccctgtgttg receptor gggggcaaggtgggggagcctggagcccctgtgtgggagggcgaggcgggggagc ctggagcccctgtgtgggagggcgaggcgggggatcctggagcccctgtgtcggg gggcgagggaggggaggtggccgtcggttgaccttctgaacatgagtgtcaactc caggacttgcttccaagcccttccctctgttggaaattgggtgtgccctggctcc 206003_at Human /DEF = Homo sapiens ctttttcttctaagcctgtgtgttataatttaccagttccccaaaatgccatttt (SEQ. ID. No. KIAA0635 gene taacgccgaactgtgtaatatacatggaaaacagctttttacaattaattttcaa 13) product (KIAA0635), agttgtaattttaaagaatttgggtgtatacctatgttaatgaaacaacagaagt mRNA. acaaaaaagaatatcagatacaaaaatcaatcgtgaagaaaatctgttcttaata /GEN = KIAA0635 tatttcattatgattgaaaaacataaaaactaacataggaaagtgaatgatcagt /PROD = KIAA063 tacttatgatatattttgtttcctcttgtggtttaataaagtgaagtgtgtgtgt 5 gene product gtgtgtgtgtgtgtgtgtgtgtgtatacctgggggtgggcagtgctctttttcta aaactaatatggcttatatatctgaattatgccctttttagtgtgtattaggatg tgggctggtttgcttttctaccacctttgtaattttatgtatcccatctcctttg tgtgaattcatatattatagcaaaatacaagagacatgggactgtttgcaatac 208369 s_at Human /DEF = Homo sapiens tacgccctcgacaggatgcagtttggtgtcccactggccaggaaccagctgattc (SEQ. ID. No. glutaryl-Coenzyme A agaagaagctggcagacatgctcactgagattaccctgggccttcacgcctgcct 14) dehydrogenase gcagctcggccgcttgaaggaccaggacaaggctgcccccgagatggtttctctg (GCDH), nuclear ctgaagaggaataactgtgggaaagccctggacatcgcccgccaggcccgagaca gene encoding tgctgggggggaatgggatttctgacgagtatcacgtgatccggcacgccatgaa mitochondrial cctggaggccgtgaacacctacgaagtcgttcagatgtgttccttaaaaagaaga protein, transcript tggaattctctgtagagcgtctcaatccacttttaaccatggatgagagcagact variant 2, mRNA. ccatttaccctgaaatagcagcttctcttgagaggagagtgacatggaagcaact /GEN = GCDH ccgtctgctgcagctgaccccctcacactgagttcacagtgcgccctccctccct /PROD = glutaryl- cccatctgggggtagtgccttatgctgg Coenzyme A dehydrogenase isoform b 208848_at Human /DEF = Human gttggttgtgactgtactattctagtatagtgaactacatactgaatatccaagt (SEQ. ID. No. class III alcohol tctcagcacctacttttgtcaaatcttaacattttgccacttcgagatcacattg 15) dehydrogenase (ADH5)  ccttcctcccctccaagaggtaacaattatccacaatttgatgtttatcattcct chi subunit mRNA, gtgttgttgtactttcactgtgtataacctaaaccatctactctttagtactgtt complete cds. ttatatatttttaagcctcatacttgctcattctacagcttttttcactcattat /GEN = ADH5 tgtataattatatctgaagctctcgttcattaattttagtcctgtgtagcagaat /PROD = alcohol tcaattacgggaaactaccataatttatctgttctccagtccagttgaaggcatg dehydrogenase 3 aagttgttgccagtttctgtattataacactgtagtggaacattcttctgcattg ggctactcgcgtgttacctaagacgt 208951_at Human /DEF = Homo sapiens, gtggcacagtggtctatgggggcaaggttatggatcgccctggaaattatgtaga (SEQ. ID. No. antiquitin 1, clone accgacaattgtgacaggtcttggccacgatgcgtccattgcacacacagagact 16) MGC: 1569, tttgctccgattctctatgtctttaaattccag mRNA, complete cds. /PROD = antiquitin 1 209161_at Human /DB_XREF = qd24g04.xl tgttcgaatgccttatagccttcctcacagcacccaggattgtgactgactctgc (SEQ. ID. No. /CLONE  IMAGE: atttttaattcttgaaacttggctttccataacatggtacatgcttcaggactac 17) 1724694 atatgacccagagagcaaggtggctgaactatagtctggaagccctcaggtaaag aggcacatctcaccactcattggttaaacaatgcatcatagcgagcacttttcct ttccctggagaatgggatgtgaagcagtagaccgcagccacgccgatggttatac agtgaagaagacttcacctcttcctattgagtttgcttggaatgctgacagcatc aggcaactctgaactgaacatttgctttgtcagaaaatatctttttttttacttt gaagtttggcaaccttcatgttaccccaaagcaaaaccattgtgtcaggagtcaa acaaatgtttagaaagcaaacatgacgtctctattgtacaacctcc 209758_s_at Human /DEF = Human taatctggtgaatgatcccgctacagatgaaacagttttggctgttttggctgat (SEQ. ID. No. microfibril- attgcaccttccacagatgacttggcctccctcagtgaaaaaaataccactgcag 18) associated agtgctgggatgagaaatttacctgcacaaggctctactctgtgcatcggccggt glycoprotein-2 MAGP-2  taaacaatgcattcatcagttatgcttcaccagtttacgacgtatgtacatcgtc mRNA, complete cds. aacaaggagatctgctctcgtcttgtctgtaaggaacacgaagctatgaaagatg /PROD = microfibril- agctttgccgtcagatggctggtctgccccctaggagactccgtcgctccaatta associated cttccgacttcctccctgtgaaaatgtggatttgcagagacccaatggtctgtga glycoprotein-2 MAGP-2 tcattgaaaaagaggaaagaagaaaaaatgtatgggtgagaggaaggaggatctc cttcttctccaaccattgacagctaacccttagacagtatttcttaaaccaatcc ttttgcaatgtccagctt 211974_x_at Human /DB_XREF = AL513759 gagagagtatgctctgtgtcgtcccagacatttctgcattccgagaaggttggag (SEQ. ID. No. /CLONE = CL0BA008ZD02 atgggtccggcaaccagtccaggttccagtaactttggtccgaaatgatggaatc 19) (3 prime) atttattccaccagccttacctttacctacacaccagaaccagggccgcggccac attgcagtgcagcaggagcaatccttcgagccaattcaagccaggtgccccctaa cgaatcaaacacaaacagcgagggaagttacacaaacgccagcacaaattcaacc agtgtcacatcatctacagccacagtggtatcctaactaccgtctttttgctagg acttaaactgacttgagtgtggcaaaaagttaacaaaaaaggagaaaaaatgaac aatcgtttgtggtttcttgggaaaacttttcataccaggtgatactattcaaaaa ccccgttgtctccctgcaagtgctgatttg 211976_at Human /DB_XREF = xz95g12.x1 tgtcttcacagcgtccctaaggaagatttttgcagcactctctggagctgagggg (SEQ. ID. No. /CLONE = IMAGE: agtgaaatttggtccagagaaggcggaaggaaatagttttcctgtttccttttct 20) 2872006 cgaggtggatgtcctcaggcttccttcacacctccttctcatgggtncggntggc agtacagtcaggctgtggaggagggctgagaagaaaggggcactggtccagcccc anggtttggtctgagacaggtacacagcagataccatcccaccttcctctctaaa gaacaggccagccacacatataaccctttccctactttactaatgtatcccttat gtggtaccagcaatggaggacaggcagacttaccccctgccatctagagagaatg ttgttattacccgtaaaacttgaccacccccatatcccactcctttttgtaaaaa caaatgcttaaacctgtgagcctgccgttcctttctatgtgttaatcagtttcct tccatttgagctgt 212394_at Human /DEF = Human mRNA for gcacctggcccataaattgtcatacttttaaagagcctattacacaaagtatcat (SEQ. ID. No. KIAA0090 gene, cagaatcatcccaagactcatttcctgattcctaattatttaaaattttgctttt 21) partial cds. aggcgaggcatggtgnctcaagcctatnntcccagcactttgggagncnaaggca /GEN = KIAA0090 ggcagatcatttgaggtcaggagtttnngaccagcctggccaacatggtgaaacc tgaaaccccatctctaccaaaaaaatggaaaaatttagccaggtgtggtggtgca tgcctgtaatcccagcctcccgagtagctggggctcaggcgtgcgccaccatgcc cggctaatttttgtatatttatggaaatgccaagagatagttcaatctgcctctc tggcaagccatggacaccaggtctgacaaactctcttactccttaagacaaatgc tcacctgatcaatatggggaaataagctgcatggtaccataatttctattctaaa agggaaaagtatctctttggtattgctttggaa 213677_s_at Human /DB_XREF = 602507842F1 gatcaacttacctgtctgatcctcgtcttacagcgaatggtttcaagataaaatt (SEQ. ID. No. /CLONE = IMAGE:  gataccaggagtttcaattactgaaaattacttggaaatagaaggaatggctaat 22) 4604891 tgtctcccattctatggagtagcagatttaaaagaaattcttaatgctatattaa acagaaatgcaaaggaagtttatgaatgtagacctcgcaaagtgataagttattt agagggagaagcagtgcgtctatccagacaattacccatgtacttatcaaaagag gacatccaagacattatctacagaatgaagcaccagtttggaaatgaaattaaag agtgtgttcatggtcgcccattttttcatcatttaacctatcttccagaaactac atgattaaatatgtttaagaagattagttaccattgaaattggttctgtcataaa acagcatgagtctggttttaaattatctttgtattatgtgtcacatggttatttt ttaaatgaggattcactgacttgttttt 214086_s_at Human /DEF = Homo sapiens gacatgtcttccaagagtgccaattactgcttnnnnnnncgcctaaagnatacag (SEQ. ID. No. cDNA FLJ11118 fis, gactgctgctcttatcagnngtagctctaggtcagtgtaatgaactactagaggc 23) clone PLACE1006011, caatcctaaggccgaaggattgcttcaaggtaaacatagcaccaaggggctgggc highly similar to aagatggctcccagttctgcccacttcgtcaccctgtaagtactcagaaccagga Homo sapiens ggactagaagactccttttggccagataagactacgttctctattgcagcttctg mRNA for aaccagagactgatgttgacacactttttttccatttggcaggaatgggagtaca poly(ADP-ribose) gtgccattaggaccagcaagtgacacaggaattctgaatccagatggttataccc polymerase-2. tcaactacaatgaatatattgtatataaccccaaccaggtccgtatgcggtacct tttaaaggttcagtttaatttccttcagctgtggtga 214585_s_at Human /DEF = Homo sapiens ttctgatgtgccagaaaccgccctgagatctgccggtcatctccatggacttctg (SEQ. ID. No. mRNA; cDNA  caccccattccatacccttcttcacctggggtaccccttccagttttccccttgc 24) DKFZp547l194 ttcccaggcccttgacatggcttacctgccttcactcccagcaccttgcccaaca (from clone ggataagctggatccccttggccttctgaatatcccagtgtcttcaggtttccca DKFZp547l194). agaccacttccctgtgggcttccaaaatggcctttatcatttctccagtctgtca /GEN = DKFZp547l194 ccctcctttcctgctcccatacacccaaggcttgtttcttcccctgtaaaaacca /PROD = hypothetical  ctgcctcaatctctggttcactcaactagtcaccatgtcctgaggcatgaagcct protein cctcagctcttggaattgctggcaaggggtgactgcctctgagtcattgtgtttt tcaaagtgatttcttttctgtagctttttgacctaagatctcagcaatttgaaca ctaacctctcccctcctggctcaagaattactccgaagtcagtctgcag 214672_at Human /DEF = Homo sapiens  tgaagcatccaccagcacttcaaggggtccatagtatttttttttttgctgcctc (SEQ. ID. No. mRNA for KIAA0998 aaagtccccaaagccttcgagcagaagtggcagtagatggttgccaatcagccaa 25) protein, partial cds. tgcagactttcactgggacaacaagaaagcagatcttctgggttttgatggaact /GEN = KIAA0998 tggcagtggggacattcagctgatgcattatataccccgtcagagcacacttgta /PROD = KIAA099 tcttttaccttccctttgccccatgcccccaaactgcttaggtcttctctgtccc 8 protein tttactgctgctgcacagagatgatataaaagaggctctttggctatttgcattn tgcttcctcttcttttccagattacagtatgaagctttattttctttgtacaagc ttaaaatttcaacatcatcatccgccaaagttgttcctcccttttcggaggatct agggggaaagaggagcattcatcacaagtttcctagagagaggagacaaatcggt gtgccattgacaacatgagccagggtaaaggcaccctttgg 214844_s_at Human /DEF = Homo sapiens  gtcctggctaattgtgtggtcattggaaaactctgcaatacaataattttcttta (SEQ. ID. No. mRNA; cDNA ttttctttttcttttttaaattcttagtgtaattgaaacgtgctctatagatatt 26) DKFZp566A0946 (from  gactctgtgttccctcttttacagctggacagaaagaagtcaatgtcacgaaatg clone DKFZp566A0946); attttctattgtagatactttgtcccttgcacttctctgaatctgtccttttgtg partial cds. gattcttgtgattttccttccaagtgtttcagttgtatgacagtcagtattgaca /GEN = DKFZp566A0946 ataaaatggcttttaattatttgttatttgtttacaccctattcctcagttatta /PROD = hypothetical ttactgtggttctgattaactactggaaattatatttgattatatcaccaattag protein ttaaatcagtgcttcgactcactcttatctgttctgttcaaaactatttgttcaa agaacccgttagtgttgtttacagggttacagtttctctcacatgctttcctcac cccnttaccccnctttttgaaagcctttattttgttcggagtctctt 217797_at Human /DEF = Homo sapiens atgcctgacggatcatttcaaacctttgtgggccaggaatgtgcccaaatttgga (SEQ. ID. No. hypothetical protein ctagctcatctcatggctctggggctgggtccatggctggcagtggaaatccctg 27) (HSPC155), mRNA. atctgattcagaagggcgtcatccaccacaaagagaaatgcaaccaatgaagaat /GEN = HSPC155 caagccactgaggcagggcagagggacctttgataggctacgatactattttcct /PROD = hypothetical gtgcatcacacttaactcatctaactgcttccccggacaccctccacctctagtt protein gttactaagtagctgcagtaggcattgctggggaagaaacaaacacacaccaaac agtactgctacttagtttctaaggctgcacagggaagggaaagactgggctttgg acaatctagaggtaatttatatccgcccccaggtggagcaacatgcgattctgga ggcacgggagtaactgaaagtgagtacatatagtctttctggtttc 217895_at Human /DEF = Homo sapiens catagctgctggaatcacacctgagaactgagatataccaatatttaacattgtt (SEQ. ID. No. hypothetical protein  acaaagaagaaaagatacagatttggtgaatttgttactgtgaggtacagtcagt 28) FLJ20758 (FLJ20758), acacagctgacttatgtagatttaagctgctaatatgctacttaaccatctatta mRNA. atgcaccattaaaggcttagcatttaagtagcaacattgcggttttcagacacat /GEN = FLJ20758 ggtgaggtccatggctcttgtcatcaggataagcctgcacacctagagtgtcggt /PROD = hypothetical gagctgacctcacgatgctgtcctcgtgcgattgccctctcctgctgctggactt protein FLJ20758 ctgcctttgttggcctgatgtgctgctgtgatgctggtccttcatcttaggtgtt catgcagttctaacacagttggggttgggtcaatagtttcccaatttcagg 218625_at Human /DEF = Homo sapiens  attcaagagagatgtccacggccgaaacatacggtgaataattcacgctcacgtc (SEQ. ID. No. neuritin (LOC51299),  gttcttccacagtatcttgttttgatcatttccactgcacatttctcctcaagaa 29) mRNA. aagcgaaaggacagactgttggctttgtgtttggaggataggagggagagaggga /GEN = LOC51299 aggggctgaggaaatctctggggtaagagtaaaggcttccagaagacatgctgct atggtcactgaggggttagctttatctgctgttgttgatgcatccgtccaagttc actgcctttattttccctcctccctcttgttttagctgttacac 218768_at Human /DEF = Homo sapiens ttggatgccctaactgctgatgtgaaggagaaaatgtataacgtcttgttgtttg (SEQ. ID. No. nuclear pore complex  ttgatggagggtggatggtggatgttagagaggatgccaaagaagaccatgaaag 30) protein (NUP107),  aacacatcaaatggtcttactgagaaagctttgtctgccaatgttgtgttttctg mRNA. cttcatacgatattgcacagtactggtcagtatcaggaatgcctacagttagcag /GEN = NUP107 atatggtatcctctgagcgccacaaactgtacctggtattttctaaggaagagct /PROD = nuclear pore  aaggaagttgctgcagaagctcagagagtcctctctaatgctcctagaccaggga complex protein cttgacccattagggtatgaaattcagttatagtttaatctttgtaatctcacta attttcatgataaatgaagtttttaataaaatatacttgttattagtaatttttt cttttgcattaccatgtaaaatttagacatttgaattttgtacttttcagaatat tatcgtgacactttcaacatgtagggatatcagcgtttctctgtgtgct 218818_at Human /DEF = Homo sapiens  ttttctaaaccacctctgggactcagctccccccgccaaaaaaaatgggtctcct (SEQ. ID. No. four and a half LIM tctgggctccaggattgtctccccactccagcatccccaaactggtactccctga 31) domains 3 (FHL3),  cccaggcccccaatcctgggctcttacagagcatccatgagtcaagccccctccc mRNA. cacacctggactccagaattcaccctctcccctgcagtctgggttcccagactga /GEN = FHL3 gtcctctccccaaatcagggctctagacccgagccctccaaacctggactctggg /PROD = four and acttaggcccccttaaatctagacttctctttataggtttcaggtctcctatggg a half LIM tgcctgggaagtccttgaaagtggactgttctcaggcttgacctgccccacccca domains 3 tccccgcggttgaggctgtgggggcagcagatcaggagcccactgataaggggcc ctagggtacagggtgctgcccagcaggtcgccaccgagtgtcttctcattttatt tcagctccattttgnccatagatgggcagaggggtgagattggctcatccccc 218998_at Human /DEF = Homo sapiens cagtcttctataatgtgcctaccaaaaagcctagtcctagcccatctgcctcaac (SEQ. ID. No. hypothetical protein  tcctctcccttttaggttgtagggaagaggccggagtgtagagtatattatatct 32) FLJ20457 (FLJ20457),  tctgtcccccttatgccaacaagatggccttcccctctgaaacaaagtaaaactg mRNA. caacactgtgacttcttaaatgagggatatgtgaaaaggctatgaaaaatacaaa /GEN = FLJ20457 ggctttcctaggaaatgtgttataatgcagcgggaagctaattcttgaaatatgc /PROD = hypothetical acattatagttactcagtctcacatactctagttactggcaaagaagttactgag protein FLJ20457 aatatgtcattcaaaggcataggggcctttgaatggaacaaatgctttcacatca tttaaagtaaaaaaaaacctccaacaactgtgaatttat 219595_at Human /DEF = Homo sapiens  ataatatcccccagtattttccatattaaatgctaattatcttttgatttctttt (SEQ. ID. No. zinc finger protein tcataagcagatctggcatttattacagggctgccgcttaagagaactcattata 33) 26 (KOX 20) (ZNF26),  atgaacgtttattatattttgcagttccatgcctgttgtccattgattgacatga mRNA. gcacccctgttttctctggagaaatacctcccctctctggggtgcttcctgtggt /GEN = ZNF26 agtgtctttcaggtatccgttccactagctacaggtgagcattttacccattgtt /PROD = hypothetical ggataatggtaatctctttttcagaattttgagtctgtaattcatttgtacatga protein FLJ20755 accagaaaatgtgggaactcattcattcttgtcccagaattctgttgagaacatc cattcattctggctaattgattacaagaataactgtggatacgatccctttagaa cctgcttctctgatctgt 219906_at Human /DEF = Homo sapiens ggatcagctcaagaccatgggttggagaattaatgttcacacttctatttggaga (SEQ. ID. No. hypothetical protein  ctttgaatcccctctacacaagctacgcaagtcaagttagttgccaagaaagcac 34) FLJ10213 (FLJ10213),  agatgacaacctattaatgctgtgagaatgtttctagatcagtgcatggatggct mRNA. ccattgctctacgggccattgtgtctgagatcccagtctttgaggagaaaaaaaa /GEN = FLJ10213 caatggttaaaaaggcattggggaaatattttgagtttgggggtgtactttgcca /PROD = hypothetical ccccattattggggagctgtcaccacgaatgttcccaaacttagcaacagcggca protein FLJ10213 aactactgggccaagatgagcaaccccacatttttgggatttaaagctcctgatg ttataccaggatcaaccatcacactccctttgcttcaaatggcgtctaccccgta agatcttgaggg 221214_s_at Human /DEF = Homo sapiens caggaaggaagggcgcagcgtcccctccttcagaggaggctctgggtggggcctg (SEQ. ID. No. DKFZP586J1624 protein ctccccatccccccaagcccacccagcactctcattgctgctgttgagttcagct 35) (DKFZP586J1624), tttaccagcctcagtgtggaggctccatcccagcacacaggcctggggcttggca mRNA. ggggcccagctggggctgggccctgggttttgagaaactcgctggcaccacagtg /GEN = DKFZP586J1624 ggcccctggacccggccgcgcagctggtggactgtaggggctcctgactgggcac /PROD = DKFZP586J1624 aggagctcccagcttttgtccacggccagcaggatgggctgtcgtgtatatagct protein ggggcgaggg 221249_s_at Human /DEF = Homo sapiens  gagaagacgccacagatttccttccctctcctccaggagaccataagatagatcc (SEQ. ID. No. CEBP-induced protein cccatcctctcagccctattcccatgcctccctctcattggaggagctgaccaaa 36) (LOC81558), mRNA. gcagccctaacgggccataacacttgaccaattcagctgctggcagagggaggaa /GEN = LOC81558 acaagtgttttcccaagtggcattttcatctcgctttcaccctgactaaagattg /PROD = CEBP- tcttaagtagcagcccagcccgcccagccccaggtgggtagtggggaggagagct induced protein ggcattcctccaggtggcaaatggcgactctatactctccgcccgccccagggct ggatggattagaaaaatccctatttttcttgtatcgatgtagagactctattttc tcccaaagacactatttttgcagctgtttgaagtttgtatattttccgtactgca gagcttacacaaaattgaagaatgttaatgttcgagttttcttatcttgtgttt 222587_s_at Human /DB XREF = 602127301F1 gacatttgggatttacttttctccaatacctgccaatacagaaaactattatcag (SEQ. ID. No. /CLONE = IMAGE: ttgttattgttatcccttgaaaagcgagggtgacaaaaacaacaaaacaccgtta 37) 4284168 taaacacatcaaaggttcattctgactgaggtaagactttccaagcccttgttag attaggccttataaaacttgtgtgcattataacctaagctgtgcaacctggtgaa gccaagagtgaactgatgtttcatttatattttcatccaaatgacattatctgca cgtttttaaaatttaaaaacaaaggactatttaaaaatacagtttattaacaaac gtgaaactactttctgttacattaggtgttccctagtgtttcttaatttct 222612_at Human /DB_XREF = yw86h04.s1 cagaatagccaagaaatccctccttttcaacgctctgtgcctggnaaccattaga (SEQ. ID. No. /CLONE = IMAGE: ggagntttaaaaaccatccctcatagcccacaattttgggtcaactctcaaaatt 38) 259159 gggaataagaaaactggcactgttgggagaaaaatcgttcttactgaaacatgaa ctggctcaggcaagcaaatagcgggagtcggcacaggaaggagtgtgtgctgcgg ggatgcgtggtggcgtcaccttcaaaactaaagtggtgccaggcggacagatgag tccttgatcttgtttcctgatcttgtttccatttgactgaattctgaaccttcat tgtcttcacagtcttgccacttgcctagtgaggcttttccgaacctggaaggaga cgtctagaaatcccaactttgctgtgtaaggaccattagctgcaagtcagtggaa gtctatagaaagcagtgtgaattccatagtggtcttgacttct 222775_s_at Human /DEF = Homo sapiens  ttgatggattttcatttcttcgcacttctgagacggcaaagccaaccacttagaa (SEQ. ID. No. cDNA: FLJ22567 fis, gccttccacatctttgtcacctgcctggctcctgctctctgatgtacctctgggt 39) clone HSI02118. agtgagatggaaatggtgcctgcagaagttggggagaaggatacttttgcacagc ctccatgatgtctttattgcaaatatggatgacaagggtctctgttacaggggcc tcagagcaccttcgtttctcctctagaccagggacaggtgtagagataaggactg gcaaccagagcctcagcatccaaagatggactgaagtgggatggctgacaggcac atnacttacgggaaagggaatttcatacatacgatttttgttttgtgggtaggag ggcttatcatcaacactg 222807_at Human /DB_XREF = 7b44a06.x1 taagatgcgctgatctctggtggttgtcactagttctnctaggtgataatgattt (SEQ. ID. No. /CLONE = IMAGE:  acccatagatggagctgttggatattattttattgtacaaattcatgtttaaaaa 40) 3231058 actttgtgactgtttctagttaagtaattttttaacctttcttgggtcatagact tctttggtaaactatgaactctcaccaaaaagatacacatgcaacatgttaaata catgttagactttgcatacaattttaggggctcatgggcctctaagcctatccat gtattccaggttaagccctctgttatgatcaatccatt 222906_at Human /DEF = Homo sapiens  gagtcatcacactgttggaatagtctgctctttnacatgctcaggtagggaaaat (SEQ. ID. No. cDNA FLJ10557 fis, aggaccaaatatatttccanagtgcctaccactgtgtcatgtttacagtgagagt 41) clone NT2RP2002537. ttaaatattgttgatgtcctgactctgtgagctcatagggagtatcttcatagta atgacatttgatcagccataaaatttacattatgttcatatgcacccaaaaaagc tagtcaggtaatgaatacccttgaagtgaatagcaattttgatttaggcagtgtg ttaggccatccttg 223175_s_at Human /DEF = Homo sapiens,  tgttctttcagctgctccaaggattgagacccaagtcatcatgaaaaaggcccaa (SEQ. ID. No. Similar to  gtacagtcttaatgcgataaatccactagctaagacgtcgagtgccaagaccagc 42) feminization 1 a  cttccagccgaggtttggacaaagtctcaggttcccgtgactcagggtaaggtgc homolog (C. elegans), tggggctgccagaggacctgccccagcaagatttttgtcaagagcgagactccat clone MGC: 4216, cagcccaggcagacgggagcaggttcttggccagcgtagacagcagcaaacagca mRNA, complete cds. gcagggaagccattctcactgcatcctccctgcagtagccacggccaggccctta /PROD = Similar ggaggagcagtgaccgggggtgtccagaaatatcctgtccctggatggaaactag to feminization 1 a  gtctcgtttggattttttttttttttttttttgccgtgttaggaaattatttatt homolog (C. elegans) aatttacaagacaggttttaactcagccgaggtgggaaatggtgtccctgtccct cccaaagcacagagcacagaaatgaggccgtttacatggcgagtctccgtgctgg tgtttaagtc 223197_s_at Human /DB_XREF = wf38a09.x1 tgttcattttccaactgcactaattgtgcatattactctgcctaatcttgtgcat (SEQ. ID. No. /CLONE = IMAGE: gttttcattgatttccctctcccggcttttgcttctcttgaaactgttgcccagt 43) 2357848 cacttctgctccaattctcttcctctctaaatagtagtttaattactgccacatc tccatgcatcagcaaaatgttggtgacatttttctagcctggcagaacagattac ttaaagctatttcanttcaaagcagactgaatgtgacttcatctaaaggcagcat taggtactgcatggaaataggtcattaacttgaaactcttatcaaaatatatttt accagtttccagaatttccagtacaggaccgcctgaagagagagccattgttcaa ttccaattcagtgtgagtgacaaagtgaaatttagaagtgaagttgtctatttga tatttaactctttattaaatctttctttaaatttctgcctgtcagtctatattgc tgtttttattatacatcagtttctttgtataacttgtgagttcccatgtgttttg t 223206_s_at Human /DEF = Homo sapiens,  atttccgggacattggcgttcccatgaccagtgtgcggctgccctgctattttga (SEQ. ID. No. HSCARG protein, clone gaacctcctctcccacttcttgccccagaaagccccagacggaaagagctacttg 44) MGC: 11351, mRNA, ctgagcttgcccacaggtgacgttcccatggatggcatgtccgtgtctgacctgg complete cds. gtcctgtggtgctcagccttttgaagatgccagaaaaatacgtcggccagaacat /PROD = HSCARG cgggctgagcacttgcaggcacacggccgaggagtacgctgccctgctcaccaag protein cacacccgcaaggtcgtgcacgatgccaagatgactcctga 223448_x_at Human /DEF = Homo sapiens  tttgcccagtttgagccagattccacagagtatatcaaggttcatcacaagacct (SEQ. ID. No. brain my045 protein atgaagatatagataaacgtggaaaatatgaccttttacgttcaacaagatactt 45) mRNA, complete cds. tggtggaatggtgtggtattttgtaaataataaaaagattgatggtttgctgatt /PROD = brain gaccagattcagagagatttaatcgatgatgcaaccaacttggtccagctgtatc my045 protein acgtgctccatccagatggccagtcggctcaaggggccaaggatcaggctgctga gggaataaatttaatcaaggtctttgcaaaaacagaagcacagaagggagcctat atagaactaacactgcagacttatcaagaagcactcagtcgccattctgcagctt cctaaaaatattttaaaaatacatttattttactaaatactgactacatttctct gttaatattgagctaaatgttaaaaaatggccagattaaaagatatcaatttgta gttctccctacaaagcaaaaattattaccctactcacttttcgtaggctacaagg atatttgagtgcctggtta 223470_at Human /DEF = Homo sapiens ttttaacaaagtctgcacctcccagtactttctttggtacctctgcttactgcct (SEQ. ID. No. PIG-M mRNA for cttgtgatgccactagtcagaatgccttggaaaagagctgtagttctcctaatgt 46) mannosyltransferase, tatggtttatagggcaggccatgtggctggctcctgcctatgttctagagtttca complete cds. aggaaagaacacctttctgtttatttggttagctggtttgttctttcttcttatc /GEN = PIG-M aattgttccatcctgattcaaattatttcccattacaaagaagaacccctgacag /PROD = agagaatcaaatatgactagtgtatgttccacaccctctgctactgtgttacatt mannosyltransferase ctgattgtcttgtatggaccagaagagagctttgggacattttttctgaacattc taagcattctagtgaaagttcccatgttccaacagaacttaaaagcaatgtttgc cttatatataaaaggtacacaataattgaggtccaccttctaggaaatcctagga ctcgtttatttgggacatggt 223518_at Human /DEF = Homo sapiens  ttttgttcacctctgcagactgtgaatcctagctgccagtttgcctattatatgc (SEQ. ID. No. DNA fragmentation caaggcatttgcaaaaatctcattaatctaaatcaaaatagctttaaagaaaaat 47) factor DFF35 (DFF35) gcatacacttcctcagatcatcaaacagactctggtccaaggttggtaatgaaat mRNA, complete cds. gactgttcctgacagggaggaatagcagggcccaatcttctgagatggcttctgg /GEN = DFF35 gtctttccatggtcagagaagatctatagtccgtcctgaggtctgtcaatgtcac /PROD = DNA aggaaaaggcaaacttgaggggatcgtcgcctgctggctaagaccagggagctaa fragmentation aaacttgaggaagggaacctgcctgggtgggtgctacttctgattcattgtcctt factor DFF35 gtccctgtcataagtacctccctattgtagatagaagggaaggaaactgttgact tgagcttggcta 223528_s_at Human /DEF = Homo sapiens  ggagaatggaacaaaagctgggcacagccttctcatggatgccagggatctggtc (SEQ. ID. No. false p73 target cttaagggaaaagggaagtcacctttggaccctcgacctggttttgtctttgccc 48) protein mRNA, cgtgtccccatgaactcccttgtccccagttgaccaacctggcctgtagcttctc complete cds. acaggcgtaccatcccatccccttcagctggaacaagaaaccaaaggaagaaaag /PROD = false p73  ttctctatggtgatccttgctcgggggtctccagaggaggctcatcgctggcccc target protein gtatcactcagcctgtccttaaacggcctcgccatgtgcattgtcacttgtgctg tccagatgggcacatgcagcatgctgtgctcacagcccgccggcacggcaggtat ggggggtgtgaccaaaatcagtgggatgtggcaggaagctgcagcccacgccagc atctgttcccacagggatttgtatcgttgtgcccgtgtcagctcctggggagatc ttttacctgtgcttactccgtctgcgtttcctccatctacggctcaggatccctc tgagagttgatgag 223570_at Human /DEF = Homo sapiens  ttttgggaggttgttgtgggagatggttgatttaggttttcaaaagctagaaata (SEQ. ID. No. mRNA; cDNA  aaatttacatgccttagatttcataaaattctgctctaattgggtggaaggtgct 49)  DKFZp434H152 gtatctaacttgtgttcctcctaaggttatgtcctaataactattcttttaggag (from clone tatacttctactttatagaaggttgcttttctttttaattttttctaacaaagaa DKFZp434H152) aagaataaagtatttattaataagaaccagaaagcacttgaaactgatgttttta complete cds.  atggctcatttagggtagatttatttatctcattaacttaaaacagctatgtgta /GEN = DKFZp434H152 tgaaataggtcacaacagaacttgaacaccaggttggtgtctgagcaatcccttt /PROD = hypothetical cttatgggaaaaacaatgttcttgtttgaacagagggtatcattgcagtcagtat protein tcacgtgtatattgttatataagttgtataatatgcttgtaaaggctgagggtga gctgtatctggatgcctttttacaatttgatt 224473_x_at Human /DEF = Homo sapiens,  gatggccccaaaggctgagggccccaaagccacttgtctcctaggatccaggcct (SEQ. ID. No. clone MGC: 2586, mRNA,  ctgggcttctgccaagaactcagggtggccctatgacttggaggagcaagatcag 50) complete cds. accgctcaaaggtccccgtgttcactgttacccagaggctcttgttactacccac /PROD = Unknown ttcattccccaccgctgccagtgccactgccaaccctgttcacaggcgcttccag (protein for MGC:  cccactccagccaggggagcagggaagaagaaggggctccctcctcttcacattc 2586) cccccgaccccaaagccagagaaagccagatggcaccagctgctccggatgtgcc tgcccacattgggggacagggccgggcctgggctcggttcccaggtttgagctct gcagcctctctcctggagtgagggggctgaagtcagaccaaaggaagaactcaga aatgtcttgtttatttgtgtttgtgaccaagcagcctctcccttcacccaggttt atggcctcgttttcacttgtatattt 224721_at Human /DB_XREF = ts83b12.x1 gcagaagaaagtcttcccacaaccccattttatttcatattgggaaaacacaggc (SEQ. ID. No. /CLONE = IMAGE: aacagcaggatgaaaaactaaacgaaactttagagaatgagctggtacaactacc 51) 2237855 cttaacagaaaacatacccgcaattagtgagcttcttcacactccagcccatgtc ctgccatctgctgctttcctgtgctccatgtttgtaaattcattgctgctgtcta aagagactaagagtgctaaggaaattcctgaagatgtagatatggaagaagaaaa agaaagtgaagattcagatgaagaaaatgattttaccgaaaaagtccaggataca agtaacacaggtttaggagaagacattatacatcagttgtcaaaatctgaagaaa aagaactgagaaaatttaggaaaatagactacagctggatagctgccctttaagc cttggagatggggaggatccttggactttgtgtttttga 225025_at Human /DEF = Homo sapiens, gaagccatcggctgagactacacagcttggggccccgaggatgaaggcgtgtaac (SEQ. ID. No. clone IMAGE: 3687782, cactgtgcccccagcgcctgggtgcagcatgccgactacagctggtaccaggngg 52) mRNA, partial cds. gcagtgccngctcagggcctgttacagtctacccctacatgccctggacacccta /PROD = Unknown tttgtgcctctgctggtgggtacaggggtggccctagtcactggtgccactgtcc (protein for ttggtaccatcacttgctgcttcatgaagaggcttcgaaaacggtgatcccttac IMAGE: 3687782 tccccaggtcttgcaggtgtcgactgtcttccggcccagctccaagccctcctct ggttgcctggacaccctctccctctgtccactcttcctttaatttatttgacctc ccactacccagaatgggagacgtgcctccccttccccactccttccctcccaagc ccctccctctggccttctgttcttgatctcttagggatcctatagggaggccatt tcctgtcct 225097_at Human /DB_XREF = 7n04b01.x1 agggcttgaacctgagtctgcccagctccagaactgagcttgcagccattagcca (SEQ. ID. No. /CLONE = IMAGE: cagctgtctcctgcatgtctgagcaaagaaaggcctttacacagcatcaccctgt 53) 3563472 gccatcccatgncaccgtgggactcagctaaaggactgtgcaaagagggggctcc tgagttggatttaggcaaaaggggcagaattcgttttgatttttagagaaaatct ctggagagtttcttttgattcatagaattccttttagatttctttccagcatacc aactagctttagtagtgctacaaccagctcttataagtaagagtgaaaaagtatt cttttcttctttaaaaaataagtttttcttgcttatagttaattctagaaaggca atactaaaggtatatattttttcaaaatgctatttttactgcacttgataattat cctgacagctctgatctctgtaatagattcactcttcagctctgggcagaaccag aggcagggttcacaccaaatttgtaaataccatatgtgggtctggtgtccaggaa ctttttct 225506_at Human /DB_XREF = ng25h11.s1 taactagttagttatcacctchtcccttaaagtcagtgacctgtgtttgatgtat (SEQ. ID. No. /CLONE = IMAGE: attacatagagtcttaagtcagtgtacagttccactggaatttgacagttgtctc 54) 935877 tacagtcatgcaactcgaagtagaaaagagtgctggacataggaagggggtgctt ggtttgaggggttaatgtgaggccttttgaaaatgaatattttgataaaagaatt cttgttttagcacagttgatgcacataagtgattctcatatttgttgtataaact ggtttaatacatttggaacatagttggattacattcatttcctgggaaagctagc ttaccatacattcaagtttataaaacaatttnccatangcaaagccatttaaaaa gttcattctgaaaattatttcatttacctacagtgaaataattgtgaactaagta gtctttctgaaaactgttgggttctaggcattcctg 225554_s_at Human /DB_XREF = zl35g07.s1 gtgattgcagcaggggtctctgccccctcgctcccaattcctagtcgtgacttca (SEQ. ID. No. /CLONE = IMAGE: tttctaaaacagagcctgaccaaccttccatgtatctccatcctcccctgctcca 55) 503964 gccagggaggactgagggagtgccccgagacccacgcacatgttggggcttctgg gccaagagtacttttatataactaatttctaaatccaaaagctcaaggaatagac agtgttctgtgacatggattggtttgaaggagttacccaccatcccagcacgata atgtcatctcccaagttggatggcagcacgatctggccctagggagcttcctgtt cccagaagtcattgtcctgggctatccagatgtccctagtaaatcttgcttcctt ctgcaatgttagtaatgccttaagctgacagttgctatttgcagaacagttttcc tctttgcttagctagtaacttgcctctgagcctgggctgatctgagaaacaggtg tgacaagagcatgaaccagaggtgcacctggggcagttccctaataaa 225584_at Human /DB_XREF = qp96b11.x1 gtgctgaattgtcactcatgggcttgagagtaggagactggagaccaaggtggct (SEQ. ID. No. /CLONE = IMAGE: agaatccagttgggcctgatgctccctgttgaaagggctccttgtggaatgaata 56) 1930845 gcacatggctcctgtggtggatctgatagtggcatagcaccaagtgcaggcctgc caaggggccacagacacagaagatgctcccggggtcccccatgtactccagacac actgcaggccacctctcccagcaggttgccagtcatgggccccatcatcatgact tctgtccaaggtactgtgtgcagaatgtgattgagattcaagtcagggcctctct gcccttttccctccagaaacaaaaccaagataatttatcctgaacacaggtgaaa aaaggaagggagggaggagaaaaagtccgggtctcacctgggattctctgtctcc tgcaacatgaaggatttagcctgggaggaggtggtgagaactctgggagagaaaa agaaggaaagaatagttttacccatgctgaagtt 225841_at Human /DB_XREF = hy16b02.x1 gacattggtggctcaaaggcccctgtcccatgctttggaccagtcttcacagagg (SEQ. ID. No. /CLONE = IMAGE: ttgagaaggccaagatagagaactctcccacacccttctgtgttggagataaatt 57) 3197451 tttcgtacctctgcagagactccttgcgtatcccaagttgaaccgcttatgtgct aatgaagagatgatgagatcagtcattgctgactcaattcctctgagcagtgatg gttctgcagtggtggctgacctgcgtaattattttgatgaacagtttgagttttg aaccatgtttatttcctgaaatttcagggtctcagcgatagttgtgctcacttag aatttagttttttttgtgtaatcctaattcaagtaatgtttttaaagtttcactg caaaagtctatgttccaagccattggacagacctgcttgagatatggcc 225947_at Human /DB_XREF = ot61d03.s1 accttcaccctacagcattacaggctttaatcagattctgctggaaagacacagg (SEQ. ID. No. /CLONE = IMAGE: ctgatccacgtgacctcttctgccttcactgggctggggtgatccttggtgcctt 58) 1621253 tgtttccacaaggccttttcctgccccctgccttgccaaagacatttaatcagca cacagctgccagactattcccacagtgctccaaatgcacatgaacaacagtgacg gctccagccttcgacccagagccccgtgcccagtgcgtcagtgggcctggggttc caggctacatcaagcactgatggtgtcagggctggtagttaccaaatcagggtta agaaacatcagggccacatttcactaccttcacagatcaaactcagcagcagtca tgactgtctgtcactacactggggatcccaattccacataagcacttttggaaga aaacagccaaagttggcctaaaattggcgctggaatttgggctgggaa 226124_at Human /DB_XREF = nx88c07.s1 ggtgcaccatgattagctcacacacaatgccaaggctgtgcttctattatctgat (SEQ. ID. No. /CLONE = IMAGE: acatagtttgacaatgggtaattctactcagaccctccctactgattggctagga 59) 1269324 tgcctgtcaggaactcattatgctactggttgtttggggatccccatagtggact actttcaggaatggcatgaattgtaaccaactgagtgctgcccccactgttacgg aagtttataaaaccttagttccagaagacccaaaggagagtactggtttgtgttt ggtgcttggcctagatccagccaccactctgaaactcancacatcttcattgaca gggagggagcccaggacatatgtgtggctcattgaccagaaggctttcttagtcc caacagccatgaaccatgcacttatggatacccagcctttta 226139_at Human /DB_XREF = 7e37b01.x1 gcttgcacagaccagcagtcacagaaatcattcttcctgctgtactgggccttaa (SEQ. ID. No. /CLONE = IMAGE: ctgcctgcaaatgtccagcactactgcataggatgccagagccaccgaaggaaaa 60) 3284617 cacagccaagtttaataataataaaaggaaaaatctcagcctgcagaactctggt tttgacccaccatcggccagatgcacatcttcagggcctgttgagcaccttctga aaagcagggctcgtaatagactccagcacattccatcagagtcaggaaaactgcg gtgagtcccagagaatctagggtgcagggcagggagcaggagtcataaggagtga taacctaaactgtgtgtagtcagcggggagggtcttatgttatcaggtgaaatga gagccagtaagttagttgatcctgtcacagatataaccctgataacaccccatag atacgcgacacgtgtgtcctgcccctgctttccccatccaacatggttcttctgt tccacagac 226308_at Human /DB_XREF = zn45g12.s1 atgggcagcagctcttagacgccctgcagcatgaactggtgaccactcagcgcct (SEQ. ID. No. /CLONE = IMAGE: cctgggagaacttgatgcttggtgattcggaagaaaatgtgcaggtgtggactta 61) 550438 ctgagcgaactcaaggacgtgacngcgaaaaaggaccttgagctccgaaggagct ttgcccaggtgctggaactctccgcagaggcaagcaaagaggcagccttggcaaa ccaggaagtctgggaagagacccagggcatggcgccccccagccggtggtatttc aatcaagacagtgcctgcagagaatctgggggagcacccaagaacacgcccctgt ctgaggacgacaacccgggtgcctcgtcagcccccgctcaggccacgttcatcag cccaagcgaagatttttcttcaagcagccaggcagaagtcccgccctctctctct cgttcagggagggacttgtcatgactcatggttacattcaggatacttgagcact ttatatactaccgtagc 226428_at Human /DB_XREF = wl62h06.x1 tccagttctttgaagcatcctctgctgggtcttggggtgtgtggatggattggct (SEQ. ID. No. /CLONE = IMAGE: gtctgatgggattggtaacccctcgctactcaagatggggggatacaaacacctt 62) 2429531 cagggaaggggagcctggttcttctcgttttccttttttttttttttttnnnaaa aaaaaactatttaattttttaatttatttttggttgttttttgcacaatgaagtt tcagcttctcaaccttctcccctacccagggctgtggacccagactggccttgag ccacagtccctctttccctcctcaccctcttccccctgcgggctcccgggtctgt ccatttgttactgtgctgtgctggggattggcg 226616_s_at Human /DEF = Homo sapiens  gtgtttgctgcggcaaggacgagccggggcgctgaagactatgctccaggaagcc (SEQ. ID. No. NADH dehydrogenase caggtgtttcgaggacttgcttctacggtttctttgtctgcggaatcagggaaga 63) (ubiquinone) gtgaaaagggtcagccacagaattccaagaagcaaagtccaccaaaaaagccagc flavoprotein 3  cccagtgcctgctgagccgtttgacaacactacctacaagaacctgcagcatcat (10 kD) (NDUFV3), gactacagcacgtacaccttcttagacctcaacctcgaactctcaaaattcagga mRNA. tgcctcagccctcctcaggccgggagtcacctcgacactgagggccctcggtgtg /GEN = NDUFV3 aagatgaaccttccaccgtcttc /PROD = NADH dehydrogenase (ubiquinone) flavoprotein 3(10kD) 226651_at Human /DB_XREF = wx26b03.x1 ttaatactttcctactgataatgaaatttaaaantggaaantttgtgagtgtttt (SEQ. ID. No. /CLONE = IMAGE: tcttgtccaatagagcctaattgtttccttttttagtgatttaacaatctcttga 64) 2544749 gggctgcacctttaaattcccagattgtcaatagacatgtacagtatatgggata aggtggacacaagtgcacatataaataaaatcttcttaagacttttaactattca tttacagtaggagagtatgtagaaatcatcatccacaagtcataattaggttgtg tgcctactgtagttttttccatttctgtattatataaacatttgcatattaaaat ttgatttttcccagagacaagtattatatactgtatctatatttaaatcaaactg tggtaatatatttctcagaaaataatgttggggactatagcctgaacatgtggac ttgaagcgacatggaggaggaggttgatcccattgtgtataag 226693_at Human /DB_XREF = xj03e02.x1 gatgtcttttttggcagtgcacagccagagaacaacacatcacacacaagaaaca (SEQ. ID. No. /CLONE = IMAGE: gttgtgctcatgtgatgggggcctcagcactaggaaggagtggactgttggcgca 65) 2656154 cgcagcagcttgaataaatctgaaagtcactacgctgcgtaagagaagccaaata aagcgcatgctgtgtacagagggtgtcgagaatgcctcctacgtgacggaaagca gatccgtggttccctgcagactggcaggagcagattccaaaggcacaggaagaag cttgcaggtagaatgtgttcattaccttctgcgcattataccacaa 226749_at Human /DB XREF = AL582429 gaattgattaccagctttacttcccgatcacacaggacagagaacagctgatgtt (SEQ. ID. No. /CLONE = CS0DL001YO17 ccctttccactttgttgaccggctgggaaagcacgacgtgacctgcacagtctca 66) (3 prime) gggggcgggaggtcngcgcaggctggagcaatacgactggcaatggcaaaagcct tgtgcagctttgtcaccgaggacgaggtcgagtggatgagacaagctggactact tactactgatccacgtgtgagggaacggaagaagccaggccaagagggagcccgc agaaagtttacgtggaagaaacgctaagggtttgctcccaggaaaggagaggaag agctatatatatgtgccgacatgtggcagacacacagtaaataatggctgaccag catgagggcagtact 226810_at Human /DB_XREF = 7a33c06.x1 ggctttaagttgtttcctatgtaaggtaatctttcttttttagtattatctaaga (SEQ. ID. No. /CLONE = IMAGE: aggatggtagattatgtcattttggaaactattgtgtcccttgtattttaaatat 67) 3220522 ttcaggaaaatgcctacgattgttacaaagatgtgtgttttacttataacataag ctctgattctccagtggccactgggccttctctgtgctctgtattcaactgcagt atgaattacagaatgctgtgcatgttcgttagtaccaataccatgtgtatgtggt agaagttgtaaccagtttctggatctgtatggtactataaaatacttattttata attctgtaaccgtatggcagtgttatgccaaaaatgtataaagagcaatagtttt tgttgcttactgctgtattttaaaatattgtttctaaaataatagagttagagtt ccttttgagtaattatttttaagaactattgccaaatatacatcctgtaaaacta ataaaagccactccatcttagataaca 226839_at Human /DB_XREF = yx78b03.s1 ttttttggccgtgtggtcatctaccacctgcgggtgcttggggagaaggtgtgag (SEQ. ID. No. /CLONE = IMAGE: acctctaggggctgtctcctccaggaagccctccgggaagcacagcaaagtccct 68) 267821 cattctgcacagaaggtttattggttcctcttgggaagggtcccctcccaccacc tgtccagaagctgcctttgaagtcagttctgggtttccccagctctggctgacca ttttgttccctgagtgtctgagtccccggcaggcggccttcactcagggtcagcg ggcaccaggttgctctggaagagcttgaggatgtggttctcgatcacctgttgca ctgagatggggcagggaaaaggtgggctgtgagcttgaatcgggagtggggtgga ggcacaggccaacctgcgctctncccttaggggacaaacagggacccttgcagag acctgcattacagagcaaagctgggagaaccgaggactcaccc 226917_s_at Human /DB_XREF = no87g06.s1 ggaagaagtgttgtcggagtcagaggcagagaaccaacaagctggtgctgccgct (SEQ. ID. No. /CLONE = IMAGE: ttagctccagagatagtcattaaagtggaaaaacttgaccctgagctagactcct 69) 1113850 aatctagcttgccattattgtgtgtgtaattatggccaaaaggacataggagatg gactaagatgtcttggaccacctttgtgt 227181_at Human /DB_XREF = qr33c07.x1 atggagaagcacacatggctcccctgtttgaaaaagggcctgaataatactctgc (SEQ. ID. No. /CLONE = IMAGE: ttctgcctcatgacatcagatgctactgttttggtttttttctttgagccccaat 70) 1942668 tcaccatttcaggatgtggatgggggcggggttgggggtaaaaacagctataaaa agcaactgcagatgctgactgactgcagtgggcagggtatgtagctgctccaaga tgacttgcatcataccccaattactgctggcatcttagttgagagtataatctgc ttggttgcctttttatgggaataaagagaataaaaggtattttaatagaataaag aaaaatttgaaaatataatggaaggtatttaaagagccacccacatagcttcacc aacccttctcacacatcaactcataaat 227412_at Human /DB_XREF = zq40h02.s1 agaaagaggtctctacacaagcccgtgattcttcatggcaagggataacatcaga (SEQ. ID. No. /CLONE = IMAGE: aatgtttcattttctgctattagtttccattcctttccccatccaggcataaaga 71) 632211 gaaacaaaagacaatgatggtattctctgtgtcctcagctttggcacttttgttg atgttgctaaggagcagtgaccttgctaaaaagactgaataatccacccactgaa tagctaacctggggaggaaatgaaaatttcctttgtggatctccccaaatccatt gttgtcaccaggccctcccagaacctcctcagttccttcacagtgcaaccctgtg tacttggcccgcaacccaatagtat 227427_at Human /DB_XREF = wd34g06.x1 ctgctgctgtcacccaaaggggaggtggccagagccctcttgccactggataaac (SEQ. ID. No. /CLONE = IMAGE: aggcccttggtgacatcccccaggctccccatgactctcctccagtctctccaac 72) 2330074 tccaaaaacccctccctgccaagccagacttgccaagctggatgaagatgagctg taactggtgaaaaccatgggggtggtgctgactcagccgcctattccccaaggag cttcagggcagtccttctggcactgctccagaattcctccttcttggtgtgtctg gagggtgggcaaggctgggagggatatcaacttggaggagaacacctagacccaa ggacttttttctgcccaaggaacacagtttccttcagctcccatccctatgcatg catcatggtccccccaaaaggaggatatgtgggtgggtgggagggctggggcagg ggccagatagaaattatt 227472_at Human /DEF = Homo sapiens  gctccccagacgatgttccaggaggcgggtgtgccagaaggggccacgtcttgca (SEQ. ID. No. mRNA for KIAA1623 aaccaccgcgctgtcctctttgagaaggagtcttactcaggactggggcctgtgc 73) protein, partial acacattgtcgcctcttttcagcacttagagattccttcctttgtctagtngctg cds. aagccagggctgaagttggcctccaaatctgggccgtctcagagngcngcgcagc /GEN = KIAA1623 ctggagttttccatctgtggccaagacccagtttttgggaggaggccctcatggg /PROD = KIAA162 tcaagccagcctgtaccaggatggggggagggggttcccaacntangccccagcc 3 protein acccagactcccccacccccactcccttttccactgctctgacctcgggcactgt tgaaatatagtttttattgcatttctgccgttttacaaaa 227603_at Human /DB_XREF = zb80d11.s1 gcaccacccagcttgggtatctggtgaattctgtggtctgcatgtccatgttttt (SEQ. ID. No. /CLONE = IMAGE: gacattctgggaagggtgngcccaggctgtgatttgccatctactgctgcaggct 74) 309909 atggatggtattcagaagggaggggagatgctgtgtgcgtgttctgaagggtttc ccactaaatggagagactgactctctccataagtatttgatttttactttatctc ctcgttgacttcacagtgtaagtgcagtttgtctctactgggtgatgcatgcaga taaatgtttatgtgaacataagaagtctgcatgtgtgggtgaactctccacatca tgtcatttattgtccatcattacgtatctgtggtgtctagcacattcctctacct tattttctgtcattgtacctacttctacctgaacacgtatt 227810_at Human /DB_XREF = xd99f12.x1 ggtattctgcagtgactatgggaaagccttgaatgttctatcggtttttaaggga (SEQ. ID. No. /CLONE = IMAGE: cttgagaattaattctggagagaatgccccattgaacatcatcaatattggagag 75) 2605775 ctttctgtttttctacatttgttaggaaacttgtgagcattcacactacagagaa acttgaaatataaagaagaagagaaagccttcagtgatgcctctgtgttagggaa aatatggaacttctccctggatgcaaaacctatgagtatattaatattggaaaat ttttcagtgattcttctctttcttgtatatgagagaacttanatggagaaacccc taggaatgtaatcagtgttaggatgcctcagcctgaactcttcactgagtggcca caattttcactgggaacaaaaagtataatcactgttttgagtgtgggatatcctt tatcagtgtctcatctgtagattggactgctggctcattaatttttttagtcttt ttttcttttaatataaacatttgtgtatagctgttccctaa 227921_at Human /DB_XREF = we90c08.x1 agctttcctttttgactgtcttattttacttaacagaatgttttgaanatttgtc (SEQ. ID. No. /CLONE = IMAGE: cttattgtagtacttttcaagatttccttatttttaaggctgaatgctatcccag 76) 2348366 tgattgtacgtgccctgtttgctgaatctactcatccttaagggtacatttgctt ccaggtaacatgtttgtgagtaatactacaatgtgcatatatctattccatgttc tgctttgtctgtttgggatatttttcatacactgattcagtaccatgtgtattcc cttgcttttgttgtctcatccgttgatgntacgtcccccaaattattgccacgac cagttgtnatgaagcttcacccttctgtattgtgctaggaattttacagctatag gttttacattatagtcttcattcatttttta 228286_at Human /DEF = Homo sapiens  gaaatgggcaaaatagctcaacaggnttttntgcaaagaagaaatacaaatgncc (SEQ. ID. No. cDNA: FLJ21836 fis, aagangcacatttaaaaatttncagnnctattnactcatcaggaaaatgcaaatc 77) clone HEP01654. aaaaccncaagacacccaatgtctacaatcaaaaagataatanctagtattgatg aggatgtggagaaattgaaattctcataacatgctggtaggaatgtaaaatgggg cagccactttggaaaaagtctggtagttcttcaaatggttaaatgtagagttacg atatgatccagcaattcctctcccaggtatatacccaagataaatgaaaacttat atccacataaaaacctgtgcacaaatgtccatagcagcgttattcataatagcct aaaagtggaaacaatcccagttccagaatgaggaaggggagaaactaatgtgtat tagctattgtgtgctaagcattcaactagattatttacaaaccttgtatcatctc aactctttaaagactgtattgcaatgttttgaa 228650_at Human /DB_XREF = wf38b04.x1 agggcattaatccccttcatgagggatattctctcatgacttaatcacctgccaa (SEQ. ID. No. /CLONE = IMAGE: agaccccacctcttaatactacatcagtgatgggttcaatgtatcaattgggtgg 78) 2357839 gagggggcacattcagaccatagcatctagtcattctggttttattaagatttat tagacctgaggcatgaaaaatagcatactggatgggacttcagcatcgatgagtt gccttagtaatactgtt 228736_at Human /DB_XREF = xa46a03.x1  ataccttgctcaaagagaccaacatttggactgtatctgaaaaantnaanangcc (SEQ. ID. No. /CLONE = IMAGE: ncgaggnatanatncaaantnttctcacnggaacngccncattcncatrtttgng 79) 2569804 ntgnnacatttctgnnaggagcttgaggagttttgggtttacagagcccttttgg tagaacttaccaagaagctgacttactgtgtaaaggcagaattaatccctctcat ggaagttactggagttttagagggtcgagcaaaacagttatacagtgcaggttac aaaagtctaatgcacttagctaatgcaaatcctgaagtgctcgtaaggacaattg atcatttatcaagacgccaagccaagcaaattgtttcatcagcaaagatgctgtt gcatgaaaaagcagaagccctgcaagaagaggtagaagagttactaagattgcct tctgatttccct 228930_at Human /DB_XREF = tu75d08.x1 gacttgtaagggtgccttaaatcctgaantactngtactnctngtattnactaaa (SEQ. ID. No. /CLONE = IMAGE: cccnatgttagtttnacgccnaagattcntgtggtggtttnacatattctttttc 80) 2256879 ccctttgttaaggtggggaggccacagcttatgtgaatgactttctcaggagtta taaagtgatacaggtaaagctaagaaaagaacagattttgataacttttgtttta actgtccagtgttagggattgtggctacagtggtctaatttttaaaaactctttt ttttgctttgttttttaacagacttatcagcaggttgcaggtgaacatggccttg aggtaaatctgtcccttgctgaatacagtttcagtagattgtttatagtagtttc aggaattgagattttttacaaaaatacaaaagttttgcttggttctgttctagat gttttcttctaaataaatgagaaagatgtttcaacaaaggctctttatgctgaat aattgtgatgcttgaagttgctaatctgctt 229001_at Human /DB_XREF = gtctccgaagaggaagtccctgactagctatataactttgggcgagttacctctc (SEQ. ID. No. 601115521F1 acttctttgtgccccagtgttctccttgggaaactggatttaggttagatgacct 81) /CLONE = IMAGE: tttaaggctccttgtatgatattttgtgatctgtacatggcagagtatagattag 3356236 gagccaaattttccaacctagtgctatggttcagaatacatagcaccccaagcgt ctggctggagccgaggatgggtcctccagtattggcacagatgttccggagccca ggaagcatcccataaccaaccttcagccccaccgccacccccagcgtattccaga gccgcttccaaaccacagcctatcctctgctccatttcactcttgccctcacaga ctttcagcctccatgctctgagacaactgtgggtaggtacatctctgttggtgga 229035_s_at Human /DB XREF = we88c03.x1 ctgccctcgctgctggaaggcaaggggccgttctcgccttggttttctaggttgt (SEQ. ID. No. /CLONE = IMAGE: gttgcggcaggagctgactgcccctaggcctagatctctgcacaacttcgctcag 82) 2348164 ggacacctgcctctgtgcatgtctcatggtgtgaatgtgtttcctgctcacaggt accgttttgtgtcatgcagttactggaatgtacaaaagcagctgtgatctttgtg agagctgcacagagcaggagtctgagagctgcacagagcaggagtctttatttgg ttcacttctggtctgcagcaaccacttgctactaaaagatggaaaagatgtacaa aaatgtcacagccctttagaaagngacattatcagaaatgtatgaccttcagtcc tccctccctctcctatgcccccaccagaccaggcggcgagaagga 229384_at Human /DB_XREF = ho39h11.x1 cacagtgagttgcaggttcaccccagcgtcagtggcgggcgggaagtggggatga (SEQ. ID. No. /CLONE = IMAGE: cacaaggacctgagtgtccaagggggcttcatggagccctcatgtgaagtcccca 83) 3039813 gcatggaccctgacacatcgtaggtcctcaacaaatgtcactccctgttgtcact ctgtttagtactaagaataatgatataaaactgggacagtaaggaaaacacaaac tgttgggacctatatctgaatctattagtctgcctaatagaaaagccaccatcag gattttggagattacaagctcactttagattagccatactggagtcagccctgga ggctcccagagatcagaacaatcccagcgcttgacaggatggctgggaaacaata catatgaatgccggaaaatgcagaactaatctaggaaaaagtgtaagaagaaaat aaacatcatctgtcattctatctatcagagataactgctgtcaatattttggttt ccttccaatattttttctattcactctgtgcat 229421_s_at Human /DB_XREF = nab38b03.x1 cctagctcctcaagtgtgcttttttaatatatagttgatatattattgaaggtac (SEQ. ID. No. /CLONE = IMAGE: tacaaaatagaaatctctggagtgcagaagttaagaaaataaccttcatactgaa 84) 3268156 aatatatccttaaaaaaacaacaacaaaaacctctatacaaatgtagtacagcat acaaatttttaaaagatggaatgaaggcacgaaccattgcaagtcttttggaaat gtatgaacgtaggcatgctaagttgaaaatagtcttaaaaaactagtgaaaactt catgtatataaaataattcagaaataaatctgctaacattcttcactttcaggtt gcatgtgtgaatccaacatgttccttcttcataaatagtcaagcgttccttcagt ggtgtttgtgtggtctgtcttcgtgctggtcaccagcctcagtatgtctggtaga cgtcggggatggggacctgaatggcagcag 229534_at Human /DB_XREF = zk70e10.s1 taagcacagtagcattccaccattgggctatgacctgaggagaatcaangtagcn (SEQ. ID. No. /CLONE = IMAGE: ttntnaggcctngtggacatcgtggatatnaaggaatgctctcgtaggagggtac 85) 488202 aagaaccccancatgattccaatagagaaggcccaggggcccatcctgctcattg ttggtcaggatgaccataactggagaagtgagttgtatgcccaaacagtctctga acggttacaggcccatggaaaggaaaaaccccagatcatctgttaccctgggact gggcattacatcgagcctccttacttccccctgtgcccagcttcccttcacagat tactgaacaaacatgttatatggggtggggagcccagggctcattctaaggccca ggaagatgcctggaagcaaattctagccttcttctgcaaacacctgggaggtacc cagaaaacagctgtccctaaattgtaatgcatttgtctgttgttgacatgagaga ttcaagatcagattctagtgttcagtaaccctatg 229570_at Human /DB_XREF = hv48b07.x1 gcctcgggagccccgaatagcagctgggagaaggggcgaggactngagcctcnnn (SEQ. ID. No. (CLONE = IMAGE: nnccnctgccggccgggctagagatacgggcgtgccccccattgtgcgcctcccg 86) 3176629 cccntccggtcccctcaccctgcggccacntggggcgtggggcggtgctcctgcc cgtgcacgtagccgctgcgagcggaggcctgctcacctggtgcctgctactcact cccccgggccggtgggcgaaggacacccgcaggaactcggcagaggagaaattca gacggctcccgagggtaggaaaagaccccggcccaccgtggaatctgaaacaccc gaccactctgccatcccatgtttcaccagtcagacccccagggcagggcagggga agcagaatgcaaactggggcaccgtttccctgaagcgtgttggccgcgtttgtcg tagtgctagaggtgcatacccttggac 230048_at Human /DB_XREF = 7j53a06.x1 tagtgcaagcaacatgccatttcaaatccgtagacttgtttctttgatactcttg (SEQ. ID. No. /CLONE = IMAGE: ctgtaggtcgccgtgaggggtagggaagcatatatactgtagggagaagtatcaa 87) 3390130 aatcatttaaggtcttttttccaaactagtgttcccctcccacatcccaataact cttggaagtctggtgctccctctaggtgaaaatcatttgctggcttatggagtca ctgttgctgagtcccatcccccagttacagtgcagtggaaaacaggtttagaatc tagaacttgtttgtatgttgtcacttggttatgttccaagtaggttagaaccatg gaaaagagattgcaaatggtagtttcttctag 230791_at Human /DB_XREF = AU146924 gtggttgtatgtgtctgatggcttatgtaaacatagaagaagtcttcagatggct (SEQ. ID. No. /CLONE = HEMBB1001899 aaaataaacatgcgcgtgttaccaaaggatatgtttacacaaaccatttgctcag 88) cctctgaaataatgaataaatgaagattttactaaaataattgggaggatttttg tgtttctgcggatgccataattgaatggcaccaaagagacttttatcagctattt tccgtgttacatgtgttagcagttcctttctgtgggttgaatacttcattctgta gttactttacacatgtttttctaagaaattgtcgtttattactgcaattctagag agttgcttgatttctcaagagaaatttagcagccagtaaaggttatttggatctg gttggtcag 230922_x_at Human /DB_XREF = ym01a03.s1 gttctcatgagatctggcacttcacccctcactctctcttgctcctgctttggcc (SEQ. ID. No. /CLONE = IMAGE: atgtggagtgctcactccccttttgccttctgccatggctgtaagtttcntgagg 89) 46241 cgtccccagaagncccatcagataccagtgccatgcttcctgtacagcccatgga actgtgagccaactaaacctcttttatttataaattaccgagtctcaggcacttt ttatagcaatgcaacaatggactaatacatatactttagcataaaaacatttaaa agagtctgaaactggagtagttaactcagtaaaaataacttggcaataaaacaca gaaaaacaatctatttgatcatgtagtgattcctaatgtaaatcctagtacaact gtcaactgat 230983_at Human /DB_XREF = 7e87b12.x1 cttgctgtgagccttttgggtttgtttcctagctccaaatcttaacttggtgtca (SEQ. ID. No. /CLONE = IMAGE: agtttcctggctuggagacaagcttttaccgacttcctctgcttgccagcaaagt 90) 3292127 catctgctaactggatattggcagcttctctgctgtcttgcagctgcttccggag tgggttccacagggattcccgtgtgttcttggttcagcttgcagagggactttca cactccctggagaccgtttcctcccattctgtctggagttttcggcctaccccaa gacaatgagatattcctgacctttccacctatttccctccaaccccaccttccga aatacatttgct 231271_x_at Human /DB_XREF = oz47c03.x1 gtcagggaccgagacaatagtggctntgggtgtagcaggtcgggagaccccagcc (SEQ. ID. No. /CLONE = IMAGE: catccggcctccctgccccgccacctcccggggcantggaggacgccggccacga 91) 1678468 caggctcctctgcttccagatgactcctgaggactacgaaaagcttggctttccc ggtgcccgggacctggccaacatgttccgtttntatgccctgagacccgaccgtg acatcgagctgaccctgagactcaaccccaaggccctgacgctggaccagtggct ggaacagcacaaaggggacttcaacctgctgtgacctgcccgcctcgcggcccct tgtggggatcgggggcaccagaggggcagaggcaccaacatctgaataaagccat t 232524_x_at Human IDEF = Homo sapiens atctacattatcttctttttactattctagaagattcactttataaaatgtgcat (SEQ. ID. No. cDNA FLJ11019 fis, cttaaggagacatactgatatttctcaatctgtgagtaatggactaattgctatt 92) clone PLACE1003611. aaatttgggagctttacatatgccacaacagaaaaagtcagaagaagcatctaca gttgtttagatgcacagttttatgatgatgaaactgtaacagtagttcttaaaga cactgtaggacgtgaaggaagagatagactcttggtccagctgcctttgtcttta gtatataacagtgaagattctgcagaatatcagttcactgggacttattctacaa ggctagatgaacagtgtagtgctattcccacccgtaccatgcatttcgagaagca ctggagattactggaaagtatgaaagcacagtatgttgctgggaatggttttcga aaagtgtcctgtgtgttaagctcaaatcttcgtcatgtgagagtatttgaaatgg acatagatgatgaatgggagctcgatgagtcttcag 232527_at Human /DB_XREF = AU146179 gagttgatggtgttgctgggttataancagcttcaaagagaaggcattttgaatg (SEQ. ID. No. /CLONE = HEMBA1007062 aaggtggaaacataatggccaggagaacaagcaaaggactaggaancagtgaact 93) tcatcttggcctcaagttcctgaggtgcatatgaataaacagtctctaacccaga gggtttcaagaaaagcagagtcctcaaaatccaaaggtagagtttccccacattg atattatactaattacacgtataacagtactttggaaaagcacaggtctctggtc acctctaaaaggcaaggttggtaaggaggtcagggtgtcacctgttggtagtctt aactaaatggtctcttcaagggatctaaggatggaaaggggatatataatggttg gattaaaggctcatcattgattagcaaattgtcccttttgtttctt 233214_at Human /DEF = Homo sapiens  aaaccagcctttggagagggcctcatggcaagaaactaagggtggcctctagcca (SEQ. ID. No. cDNA FLJ11900 fis, gtagtcagcaagaaaacagatccttgttctagtagtgtgccaggaactgaagatt 94) clone HEMBA1007341. gccaacaaccttgttattttggaagtgaatcctggttcagtggagccctagctga gaccttagctctggctaacaccttgattgcagtcttttgagaccaggaaacagaa agaagccagctaatctgtgcttggactcctgacccacagaacctgtgagataata aatgtgtcttgttcttaacacaccagatttgtggtaatattgttacacagtgtag aaaactaacaaactaggcctcaaaataaatctataaacagttttgcaggtacact gtagaacacacaataaaaagtagccacagaaagagacatgagtgaataccagcag gagcttctattta 233302_at Human /DB_XREF = AU146285 tgtgtgtctaagcaattctggcccctggctcccaccaccctaccctctccacaaa (SEQ. ID. No. /CLONE = HEMBB1000025 ataatagacattaggggaggtaagggancagaagaggtctcttngcagatattat 95) atttttaaaaantggttctatgntaataagcagcagctaaggagacagaaagnca gtagatgaagagagtgccaatatcttccatggggaaaaatgaatgaactgaaaga gaatattatttttctagaatacagaaagctgtcctctcacagatcagctggaatt ccaaggtggattatggacttcttctaactcccattgatagtgcttcttaccaggt gaagggaagggctactttttcctaaaggagaaaaaagctttcagacaaagctcgt accaacccctgaactgcaaatttgctcaagtgaccgtgcatacttatattcctaa tttaaatgattatttatgtcaaacgctcattgtgaaactt 233429_at Human /DB_XREF = qm62e07.x1 ttgggcaccacttccatcaggaaaacagtgtgcaagatggagaaactaaggacaa (SEQ. ID. No. /CLONE = IMAGE: accccagagaaactggacaaacccagcagaagaaaggaagaactgcaactcagaa 96) 1893348 atcacataaccaccaagcaggtntggaccacacatgctaaatgtgcatccactat ggcgagtcccaggcctttaacagcagggactaaggagggcagaggctgacaccaa ccccctttcatactgtagcactacatccctctcagataccagtttaacacgaagt ctccctgtttgactcctgtgagttgtgtattgaactanaaagtgnttnctgagtt naaaataaaagcgcnntnncnnnnnnanaannnanattgtgtatcttgacttctc aatgatagcaagttacattttgcagttttcttcctatacccacaaatgaaactat tcagacttaaatatcttcctgtgtgcctaaacgtt 233440_at Human /DB_XREF = taagaaatgtcgaaggaggccgggcgcggtggttcatgcctgtaatcccagcact (SEQ. ID. No. DKFZp761l07121_s1 ttgggaggccgaggcgggcggatcacgaggtcaggagatcgagaccatcctggct 97) /CLONE = aacacggagaaaccccgtctctactaaaaatacaaaaaattagccgggcgtgtgg DKFZp761l07121 cgggcacctgtagtcccagctacttgggaggctgaggcaggagaatggcgtgaac ccgggaggcggagcttgcagtgngccangatcgcgccactgcaccccagcctggg agacagagcgagactccgtctcaaaaaaaaaaaaaannngacaaaggaaattctt ctagttcctttaaggatttctctagcacaggatcagagaggatcttggttattgg tgactggtgagattctgttgggtgtttggaagcttcaaatgcatggagccacccc ttaaaaatgtctcactggaggcaggcacggtggcttatgcctgtaatccmgcatt ttaggaggccgangcaggtggatggcttgagtatatatacttcgcgagcaccgtg g 233493_at Human /DEF = Homo sapiens  atgagaacatggtcttggccggagcaatttctgggctggtgggacccttgtccac (SEQ. ID. No. PAC clone RP5-988G15  aattgtagtttcatatatgtgcatcctctgtgctatccttcagatccaatcaagg 98) from 7q33-q35 gaagttcagaggaaagccttccgcacctgcttctcccacctctgtgtgattggac tcgtttatggcacagccattatcatgtatgttggacccagatatgggaaccccaa ggagcagaagaaatatctcctgctgtttcacagcctctttaatcccatgctcaat ccccttatctgtagtcttag 233599_at Human /DEF = Homo sapiens  ctgtgttgttttgctggtggccacgaatccgaaaggcccatgctgcagcgtgccc (SEQ. ID. No. cDNA: FLJ21498 fis, ntgctttgagtttggttgatatgcnttaataagaacattagttttcntgggagaa 99) clone COL05627. tttggtagcacccgttcttcccttcactgtgtgggggaaatagtgttgattgaaa ggaagaggactccgagattggattggagcaagaaagtgtgggtatcgtgtgttgt gactgtgtcttctccggggtgctgcttcactggaggtctccnttcagggtctggc cctcatgcctggccccaggtgctcgtgtgcacgtgagcggctcttcctgctgact gactacagctaatt 234735_s_at Human /DEF = Homo sapiens caaagattccctcgaatcctcgtgctccatctgaatcgattttctgcctcccgag (SEQ. ID. No. clone PP1490 gctccatcaaaaaaagttcagtaggtgtagactttccactgcagcgactgagcct 100) unknown mRNA. aggggactttgccagtgacaaagccggcagcgtccactatggccactacacagcc /PROD = unknown ctgtgccggtgccagactggttggcatgtctacaatgactctcgtgtctcccctg tcagtgaaaaccaggtggcatccagcgagggttacgtgctgttctaccaactgat gcaggagccaccccggtgcctgtgacacctctaagctctggcacctgtgaagccc tttaaacacccttaagccccaggctccccgtttacctcagagacgtctatt 235363_at Human /DB_XREF = 7l45h09.x1 cccgaagagcacccagcatatagctctcatttgttgattctgttagatcatgatc (SEQ. /CLONE = IMAGE: aatgttaagcctaaaaacaaggtggccacatcagtggtttgtaacccatgtttat ID. No. 3524585 tctaatcagtcaatctggggctatatataatagtagttgaatgtttatagtacta 101) cccttnggaaaattcccatatattcncncccagcatggatataaatacnggaaag atttcccattgagtacttctctttagcactccagntaacactagacaaataagca cctaaatgccgagtgtttgtcagttttaaaattagaaaagaaggcaagttgtttt cttgtctacctgtttaataaattttttattgnccaagtanntatgttcatttgat ttaatacgttgaaatgtagtttaaaatatatattcaaataactaacaa 235467_s_at Human /DB_XREF = 602272817F1 cctctcttaaagcggcaccaacgtgagagagacaggcagacagacagaaagccag (SEQ. ID. No. /CLONE = IMAGE: aggcttagggaaactctggaacccagacaagaatcttacgctgggaaagactcag 102) 4360612 atatccttgtttgcacaggactggtggaaaatctcccatgcgaccctcggggccc agagccatctgggtctgatgttctgttccattgtacatcgaagagatatatatgc acatatagtatctatattcatacatattatactcttgtgtgtagtgca 235634_at Human /DB_XREF = 7a17e03.x1 tcatcaagcctttcgttttcaaaccaccatttgtcagccttgaggtagagagaca (SEQ. /CLONE = IMAGE: tatagatttgaaaatactttcttaagagatcatgtaactatataactctgaattt ID. No. 3219004 aaaaattgaggggggagggataatttcaacccactgcctcttaccagaaacattt 103) ttttaaatctgtaactgctttagtgttaacagggtgcaaggtggtttttgtcccg tattgttcttaaaaggactcatttattgtgattgtattgtactgtatgagaacaa antcataaattgccttgtattgtttataatagaccataccacgtactacttcagt attatgttccaagtattcagtgatgcatgttaacagttaggtcctaaaattctgt ggtgctaattctcccatacccaatggtgcttttgtggatgctaactgcacacatg ctgaac 236312_at Human /DB_XREF = oc10d11.s1 cctatccctggccaaggaagtatgcaaattgtattgtggtttttgaagtttaggt (SEQ. ID. No. /CLONE = IMAGE: gatctcttccttctatccctagccaaggaagttcatcctgactccccaacaagca 104) 1340469 tatcaaaaggagtgtttcgtcacctttttcctcttaccctttacatccttttagc aataaagtgttcagaacaaactggttttcctttactgtgctttgcaaaacttatt catgttttattgggtgactttgtatttacactttcctcagatagtctgttgtcag atgactttgaccaatgattgggaggaaccaaatacagaggattttatcctatgcc taatctatattgtctacagagtaaatcaggtntgaatttgtgaacagtaatgaaa caattttccaactaatcagaagaattgtttgttaagtaaccttaattactcagtt tttggtgaattgtttgcggcttaacttg 236875_at Human /DB_XREF = wb57e03.x1 gaaggagagctgttctgcatccataaaaaccagttaaaagggatttcataaggtc (SEQ. ID. No. /CLONE = IMAGE: tgaaattgagaactttcccaagaatactgcatcttgttctcttgtgcaatataca 105) 2384860 gacgtgtgaatattcctaacagtaaccaaatgggtgcactctctgtgaaaacgca tctttcaaagagttttttaaacaaaggagactcctgggcctttagaaataattgc cacaaactgcaaaaacaatctccaacctcccacttctgtaattctcatctgttgt cttactagaaaatttatttctctggtaataatgttataattgatatccctgtctt ctcaagatgtaaaatacttgtaaaaacttctctgtccatcagaaaat 237023_at Human /DB_XREF = 7q84f05.x1 tagaaagataattccgtctctcctttggcagtaggcatgtccctgtgagggagga (SEQ. ID. No. /CLONE = IMAGE: gatcagcaggatttttccaagcacctgtcaaaaccctgntgatcaaaacagaaca 106) 3704985 tancaataacaaagaatggccaaaaccagctcggaataggaattaaaatgcattt gcataagatactcccaccagggccatgacagtttacaaatgatcccacggcaata acccaggaattatcttatatggttccaggaacttcctgttcctagtttatgaata acctgcctcttatttagcatataattagcagtggbtataaatatagctagccagc aatcctggagtgctattctacctgtggggtagccctgctctgtctgtggagcagc cattttgctgtac 239496_at Human /DB_XREF = xy02b11.x1 gtagagatgggctgtcttgccttagagacattaaggtctgttataaagctataat (SEQ. ID. No. /CLONE = IMAGE: aacgaagacagcctggtattagggtgccagtgtagttacagacaaagagaccaat 107) 2851965 ggaacaggataaaaagcccataaataatctcatgcatatatgcacacttgactta caatggaaggagtattgcagatcagtggggagagactgaactaatcaataaatca tgcagttacaagatcatacatgtggagaaacaaaatgaaaccagatcctgaagta cacaaaaaatcggttccaggtatattgaatat 240130_at Human /DB_XREF = yd76e12.s1 attacttgaccaattttcatagcaaactgattggnttcacttatccccccactga (SEQ. ID. No. /CLONE = IMAGE: actgttaagacctggcgagatcctttttatagttctttaaacttccaggactttc 108) 114190 tgcttatcttcaggaaggacagtggaccttcaggggagaggagaaggaggaaatt tgcatatttaaaatgtgtgatctgagccaaacgctcttcagctaacttgatctcg catcattttcccagcttcctttgagaattcagaatcaaaattcaggcatcaccat ctagtgaccacagggtcctgcaccccagcccaaacctggggancccttagggata atgccctttctcatttgtcttt 241395_at Human /DB_XREF = AL572553 attctgactgtatcactgaaaggctgtgtagctgtgtgaccgtaagcaagtcact (SEQ. ID. No. /CLONE = CSODI008YD03 taactccagattctcagtgctgtcatctataaacagggatgaatgaatatacacc 109) (3 prime) tcagagttgttaagaatccaatgagaaaatcacgggtaacccttatataaatggt tgtgaaacatttcaaagatacaagcatccttggcctttgcagcccagaatcatcc ctccacatttttcctacaatccaaccacatcaagaaatgataactgctcagaaag tttatcaatatttaccaaaactcatggatttaaaataaacattaagtttctncaa taaaaaannnnnnaattctatgccatttgtactcccttgatcttcaccctatttg gcaatatcaactttttttttttgagatggagtctcactttgtcacccaggctgca ttgcacgtggtgcaa 242171_at Human /DB_XREF = zi55d08.s1 gtcattgctggtcaatgaagcatactaacagaccaatctgagcagtaattgtcct (SEQ. ID. No. /CLONE = IMAGE: tgcataagcaagattttttttttttttgatggtaatgagtgatttcaaaaatacg 110) 434703 tttaggctgggtatggtggttcttgcctgtaatcccagcaactttgggaggccaa ggtaggaggatcactcgaggccaggagttcatgaccgtcctggtcaacagagtaa gacctcgtctctgcaaaacaaaataaaataaaataaaataaaaaacttaaaaaat catgcacctatagtcccaactgctcaagaagctgaggtgagattgcttgaggcca ggagttagaggctgcagtgtgtgattgcccactgcattc 242602_x_at Human /DB_XREF = wz04g07.x1 ttcttgacccattacaatctcttctacgggcaaagctgagggactgttgacattt (SEQ. ID. No. /CLONE = IMAGE: agggatgtggccatagaattctctctggaggagtggcaacacctggacattgcac 111) 2557116 agcagaatttatatagaaatgtgatgttagagaactacagaaacctggccttcct gggtattgctgtctctaagccagacctgatcacctgtctggaacaagggaaagag ccctggaatatgaagcgacatgagatggtggatgaacccccnggattggattttt cattactgtgaagaaaaacactggaattttgataaggagttctttaaatctacag gtcactttggataat 242606_at Human /DB_XREF = ggatttagttgccatgtatcttcagtttcaattttnctttgtcttttcataacat (SEQ. ID. No. DKFZp434B1827_r1 tgactttttttaagagaacagctggtggttttatagaattccatcaatttgggtt 112) /CLONE = tgtcagattattggcttatgattagattcagttatgaattttggcaaggatattg DKFZp434B1827 cagaagttatgataggttcttcttagtgcaacttatcacgatacacatgatgtct gtttgtcccattattggtgatgttaacttccgtaacttgctccattgaaa 243003_at Human /DB_XREF = AV702197 agtattgaaattcctcgagccgctgcttttctcactccataattctggccagaat (SEQ. ID. No. /CLONE = ADBCOH08 ttggtacttaaaatattttgtctaaaatattacaatagctacttaagtcatctcc 113) ctgactccactctgttgtctttcagggcgtcgtccacactgtagccaaagtgatc ttataaaaacataattctaatcatggcactcttctgcttaaaaatgttttaatgg ctttccgttaggttaaaatttaaaagtcctttgtagcctgtgagactctacatga gttgactccctagcttcatctttgagcatcttatttctttacttattataccatc agttagagttgattgttatataatccacagaagtgaattctgtccgatttaagc 243185_at Human /DB_XREF = nz37f07.s1 ttccctccccagtcttagagactgatcactggggcagagtgacattttcccacaa (SEQ. ID. No. /CLONE = IMAGE: tgctggctcattattttcctcctggaatngcaaatccaagggacaagtggtacag 114) 1289989 cctgncaccnatccagaaggggagggaatcccaccagaggtgccctgaaacaaag aanacaagtaacttcaaaaccacatcctaaaatctggacctgtgacaggacagat ggaactctggattgtttgattctatcagcagaacagaggaaggaaatgttttaaa acgagattatgttattttccccagttattatgaagccttcctgaaatgaacttta aatatcggccaccactttcatgaggctgaatgggattcagcaattaggagcgttg cagggaagtgtggcagggcagaggtgggacaaattgcagatccctgtggggtccc ttggttaggtgacaattagtctataaaacacagctgtgtgtgttagggagggagt ggtgtctttaaaaagctctgtgcccaataggaacat 31826_at Human Cluster Incl. aaccctgggtctaggcgagccacagggtgaggtcaaggtgagcattctgggaaca (SEQ. ID. No. AB014574: Homo sapiens atatttgggctcagagggtgggttggccaccttctgagccccacccccgccagac 115) mRNA for KIAA0674 ctggtgaagaggatnnnnnnnnnnnnnnnnnnnnnnnnnnnnannnnnnnnnnnn protein, partial cds gttggaagaaggactggtaggttcccctccaagccagtcacctgtaagagtcctg /cds =(0,3704) tcctctgccagactttttnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnagccc /gb = AB014574 tcntnnacctgaatccagtgctcaactgtgccccggcaacaagacctgggctgag /gi = 3327161 gtctccctggtagaacnnnnnnnnnnnnnnnnnnnnnnatcccagtgcagtcaac /ug = Hs.14799 agcctggcctatagtcctgggacatgtatcttcttctttgccttaaatctgatac /len = 4263 aagaggtcaat 35150_at Human Cluster Incl. cactgtacgagtgaggcctgtgagagctgtgtcctgcaccgctcatgctcgcccg (SEQ. ID. No. X60592: Human CDw40  gctttggggtcaagcagattgctacaggggtttctgataccatctgcgagccctg 116) mRNA for nerve growth cccagtcggcttcttctccaatgtgtcatctgctttcgaaaaatgtcacccttgg factor receptor- acaannnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnggcacaaacaagactg related B-lymphocyte atgttgtctgtggtccccaggntcggctgagagccctggtggtgatccccatcat activation molecule cttcgggntcctgtttgccatcctcttggtgct /cds = (47,880) /gb = X60592 /gi = 29850 /ug = Hs.25648 /len = 1004 64474_g_at Human Cluster Incl. ccatctgaagcaagagtccagcgttctgccgtgtctgtcccccaccatgccccct (SEQ. ID. No. AA203219: zx56d02.r1 acaggcnnnnnnnnnnnnnnntttttttttttttctgtcnnnaannnaannnnnn 117) Homo sapiens cDNA,  cntgtgggccgcccacaacatatccttccctcactacctgtgtgaccaaggttgg 5' end cttctgttgacctttaaaaaagaaaccctcaactcaaattgctataattagacac /clone = IMAGE-446499 ttgcttctgtcttgcntcctgtctgcagctgtgaatagtcatttgactgtgactg /clone_end = 5' ttgcccttagccagccagatgcgcctgtgaaccaaagcttcgtgcacatgtgttc /gb = AA203219 ccctaaaggttggggagcctcgctgtgtcttgctgttcccaggcaccaccacagc /g1 = 1799058 agntgnngccatactcttgtggtctctgtgcg /ug = Hs.59457 /len = 901 91617_at Human Cluster Incl. tttctgtcaggaaaacaatgttggcctgtgggccgcccacaacatatccttccct (SEQ. ID. No. Al028241: ow01b03.x1 cactacctgtgtgaccaaggttggcttctgttgacctttaaaaaagaaaccctca 118) Homo sapiens cDNA, 3' actcaaattgctataattagacacttgcttctgtcttgcctcctgtctgcagctg end tgaatagtcatttgactgtgactgttgcccttagccagccagatgcgcctgtgaa /clone = IMAGE-1645517 ccaaagcttcgtgcacatgtgttcccctaaaggttggggagcctcgctgtgtctt /clone_end = 3' gctgttcccaggcaccaccacagcaggtgctgccatactcttgtggtctctgtgc /gb = A1028241 gcccccccccccccnnnacccgtctgccaagcatgggtatgaatcgtgcacacag /gi = 3245550 ccatgcttcaaggccggggcaggggagcctgtgctgatgccatccagngcactgg /ug = Hs.59457 gctgtgcctggaaggcgagccttgattgtctgaacacataaagcaaactgtccag /len = 752 

The invention claimed is:
 1. A diagnostic kit containing a microarray, the microarray comprising the nucleotide sequences of SEQ ID NO.:1 to 118 attached to a substrate, the nucleotide sequences corresponding to the predictive genes of a gene expression profile obtained by a method for providing a gene expression profile being predictive for the specific response of an individual tumor to Avastin, the method comprising the steps of: (a) xenotransplanting human tumor material of at least five different tumors into at least one suitable test animal, (b) determining gene expression profiles of the resulting tumor xenografts, (c) treating said at least one test animal with Avastin, (d) evaluating responsiveness of the tumor xenografts to Avastin, (e) identifying the gene expression profile of each of the tested tumor xenografts, and (f) determining the predictive genes in the gene expression profiles by comparing the gene expression profiles of responsive tumors, no-change tumors and progressive tumors, wherein step (f) comprises the steps of (i) dividing the complete set of gene expression profiles of the tumor xenografts into sub-sets, each of the sub-sets missing one of said gene expression profiles, (ii) determining the predictive genes in each sub-set, and (iii) obtaining the gene expression profile being predictive for the specific response of an individual tumor to Avastin by setting up the intersection of the predictive genes of all sub-sets.
 2. The kit according to claim 1, wherein in step (f) a tumor xenograft is considered to be responsive when its T/C (therapy/control) value is less than 25%.
 3. The kit according to claim 1, wherein in step (f) a tumor xenograft is considered to be no-change when its T/C (therapy/control) value is ranges from 25% to 42%.
 4. The kit according to claim 1, wherein in step (f) a tumor xenograft is considered to be progressive when its T/C (therapy/control) value is more than 42%.
 5. The kit according to claim 1, wherein in step (ii) an expression profile of 300 genes is determined for each sub-set. 